Principal Software Engineer

Position Overview

• Location Type: Hybrid
• Employment Type: Full-time
• Salary: (Salary information is missing from the provided text)

Description: Genesis Therapeutics is building a world-class software team to solve problems in drug discovery through machine learning, biophysical simulation, and computational chemistry. We are seeking a Principal Engineer with strengths as a technical lead and software architect, who is excited to help develop new medicines and play a critical role in building out our software platform.

Requirements

• Deep thinking and reasoning from first principles
• Ability to balance attention to detail with architectural thinking
• Investigational curiosity to find the root cause of problems
• Comfortable working across all levels of the software stack
• Ability to build intuitive APIs
• Mastery of writing production code and driving projects to completion
• Strong background in both chemistry and computer science (experience with both is highly desirable)

Responsibilities

• Provide technical insights to the Head of Engineering and Head of Computational Chemistry on software architecture.
• Scale the company’s data infrastructure to handle billions of datapoints and hundreds of thousands of parallel quantum chemistry and molecular dynamics jobs.
• Lead, mentor, and coach engineers – both from chemistry and computer science backgrounds.

Company Information

Company: Genesis Therapeutics

Mission: Genesis Therapeutics is unifying AI and biotech to discover novel and breakthrough treatments for patients with severe and devastating conditions.

Overview: Genesis was founded on groundbreaking molecular ML research and has established itself as the industry leader in AI for small molecule drug discovery. The company has created the industry's most advanced molecular AI platform called GEMS (Genesis Exploration of Molecular Space) to accelerate and optimize small molecule drug discovery and enable the discovery of novel first-in-class and best-in-class small molecule drugs for challenging and/or undruggable targets. They have leveraged GEMS to build an internal pipeline with multiple programs against high-value targets, including data-poor and canonically undruggable targets where GEMS is uniquely advantaged. Genesis has signed AI-focused platform collaborations with major pharmaceutical companies, including Incyte Corporation (Feb 2025) and Gilead Sciences (Sept 2024).

What We Offer

• Opportunity to work on high-impact tools and products accelerating the discovery of new medicines.
• Strong technical coworkers in AI, software, and chemistry.
• Competitive salary and equity.
• Medical, dental, and vision insurance, and a 401(k) program.
• Reading and discussing 1-2 machine learning or chemistry papers weekly.