[Remote] Principal AI Software Engineer, Enterprise AI Platform at Natera

United States

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Not SpecifiedCompensation

Senior (5 to 8 years), Expert & Leadership (9+ years)Experience Level

Full TimeJob Type

UnknownVisa

Healthcare, Technology, AIIndustries

Requirements

Hands-on technical leadership in engineering excellence, low code platform design, and applied GenAI engineering
Expertise in architecting scalable, secure, modular low-code platforms
Proficiency in building agent orchestration runtimes, including task queues, state management, and inter-agent communication
Experience with DevOps, CI/CD pipelines, and configuration management for large-scale deployments
Skills in Python and TypeScript for pro-code development
Knowledge of enterprise integrations, MCP (Model Context Protocols), RAG (Retrieval-Augmented Generation), vector databases, and retrieval pipelines
Ability to implement prompt optimization, evaluation guardrails, and feedback loops

Responsibilities

Design and implement the core architecture of the Enterprise AI Platform (low code, modular, scalable, secure)
Build the agent orchestration runtime, including task queues, state management, inter-agent communication, and support for long-running, resilient AI workflows
Develop APIs and services for automation, evaluation, agent lifecycle management, data and MCP connectors, prompt optimization, abstracted AI services, intelligent data extraction, and reasoning
Create an intuitive low-code visual builder for drag-and-drop agent workflow composition
Provide a pro-code extension layer for authoring and deploying agents in Python/TypeScript within the same framework
Ensure unified runtime for low-code and pro-code workflows, including orchestration, evaluation, governance, transparency, debugging, workflow traces, and output explanations
Implement experimentation, versioning, evaluation-based comparison, and rollback features
Build robust orchestration system for short-lived and long-running agents, with shared state, scheduling, dependency resolution, event-driven execution
Integrate agents with core enterprise systems for secure real-world actions
Develop mechanisms for persistence, checkpointing, recovery, human-in-the-loop interventions, and self-assessment
Architect evaluation-first framework for monitoring and improving AI agent performance
Integrate with Model Context Protocols (MCPs) for plug-and-play connectivity
Build RAG services for retrieving information from unstructured data using vector databases and retrieval pipelines
Implement automated prompt tuning, evaluation, and feedback loops
Establish DevOps, CI/CD pipelines, and configuration management for smooth scaled deployment

Skills

Key technologies and capabilities for this role

AI PlatformAgentic AIGenAILow-CodePlatform ArchitectureAgent OrchestrationTask QueuesState ManagementDevOpsCI/CDVisual BuilderDrag-and-DropAPIsPrompt OptimizationEvaluation Guardrails

Questions & Answers

Common questions about this position

What is the salary range for this Principal AI Software Engineer role?

This information is not specified in the job description.

Is this Principal AI Software Engineer position remote or does it require office work?

This information is not specified in the job description.

What key skills are required for the Enterprise AI Platform Engineer role?

The role requires expertise in platform architecture design, agentic orchestration including task queues and state management, low-code/pro-code development with Python and TypeScript, DevOps/CI/CD pipelines, and enterprise system integrations.

What does the work environment or team culture look like at Natera for this role?

This information is not specified in the job description.

What makes a strong candidate for the Principal AI Software Engineer position?

Strong candidates will have hands-on experience in technical leadership at the intersection of engineering excellence, low-code platform design, and applied GenAI engineering, with the ability to architect scalable AI platforms and build agent orchestration systems.

Natera

Genetic testing and diagnostics solutions provider

About Natera

Natera focuses on genetic testing and diagnostics, providing advanced solutions for cancer patients, transplant patients, and individuals assessing hereditary health risks. Their main technology is cell-free DNA (cfDNA) testing, which analyzes DNA fragments in the blood to detect minimal traces of cancer and assess organ health. Natera stands out by offering specialized tests like the Signatera ctDNA test and Panorama NIPT, along with genetic counseling services. The company's goal is to improve patient care and health outcomes through accurate genetic testing.

Austin, TexasHeadquarters

2004Year Founded

$149.9MTotal Funding

IPOCompany Stage

Biotechnology, HealthcareIndustries

1,001-5,000Employees

Benefits

Flexible medical plans

Investment options

Time off

Workplace perks

Risks

Hindenburg report accuses Natera of deceptive sales practices, risking legal challenges.

New Prospera Heart features may face slow adoption by healthcare providers.

Fetal RhD NIPT demand may drop post-RhIg shortage, affecting future sales.

Differentiation

Natera's Signatera test offers personalized ctDNA analysis for cancer patients.

Prospera Heart test uses unique Donor Quantity Score for transplant rejection detection.

Panorama NIPT test is a leader in non-invasive prenatal testing with 2 million tests.

Upsides

Increased adoption of liquid biopsy techniques boosts demand for Natera's cfDNA tests.

AI integration enhances accuracy and speed of Natera's cfDNA analysis.

Growing personalized medicine trend aligns with Natera's customized genetic tests.

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