Principal AI Engineer

Position Overview

• Location Type: Onsite (San Francisco)
• Job Type: Full-time
• Salary: Not specified

Arine is a rapidly growing healthcare technology and clinical services company based in San Francisco. Our mission is to ensure individuals receive the safest and most effective treatments for their unique and evolving healthcare needs. We address the significant problem of medication-related harm and waste in the US healthcare system, estimated at over $528 billion annually, by leveraging a software platform (SaaS). Our approach combines cutting-edge data science, machine learning, AI, and deep clinical expertise to create a patient-centric view of medication management and deliver personalized care plans at scale. We focus on improving the lives and health of complex patients who have a substantial impact on healthcare costs and have traditionally been difficult to identify and address. Backed by leading healthcare investors and collaborating with top healthcare organizations, we deliver recommendations and facilitate clinical interventions that lead to significant, measurable health improvements and cost savings.

Why Arine is a Great Place to Work:

• Outstanding Team and Culture: A shared mission unites and motivates us to do our best work, with a relentless passion for innovation to be the market leader in medication intelligence.
• Making a Proven Difference in Healthcare: We are saving patient lives and enabling individuals to experience improved health outcomes, including significant reductions in hospitalizations and cost of care.
• Market Opportunity: Arine is backed by leading healthcare investors and was founded to tackle one of the largest healthcare problems today: non-optimized medication therapies, which contribute to 275,000 lives lost and $528 billion in costs annually.
• Dramatic Growth: Arine manages over 18 million lives across prominent health plans after only 4 years in the market, ranked 236 on the 2024 Inc. 5000 list, and named the 5th fastest-growing company in the AI category.

The Role: Principal AI Engineer

We are hiring a Principal AI Engineer to lead the evolution of Arine’s decision intelligence systems. In this role, you will serve as a key architect and hands-on technical leader, driving the design, implementation, and refinement of AI-powered systems that support real-time, personalized decision-making. You will partner closely with AI leadership, product managers, clinicians, and engineers to shape the long-term architecture of our platform and deliver systems that are scalable, resilient, and aligned with our mission. This is a high-impact role for someone who excels at navigating complexity, bridging ML and systems thinking, and influencing teams through deep technical insight and collaboration.

What You'll be Doing:

• Own the architecture and technical roadmap for Arine’s next-generation AI decision systems.
• Design and implement scalable, intelligent frameworks that blend ML models, rules, and data-driven logic.
• Lead technical design discussions, make high-stakes tradeoffs, and drive execution across multiple teams.
• Collaborate with stakeholders across engineering, data science, clinical, and product to ensure solutions are clinically meaningful and technically sound.
• Ship reliable, maintainable code that integrates AI into operational workflows at scale.
• Set and evolve best practices around AI system design, observability, model integration, and governance.
• Mentor senior engineers and help grow technical excellence across the AI team.

Who You Are and What You Bring:

• 10+ years of experience in machine learning.