Senior Product Manager, ECD

Position Overview

• Location Type: Remote USA
• Job Type: Full-time
• Salary: $132,100 - $165,100 USD

We are seeking a Senior Product Manager to drive the development and lifecycle management of innovative products for early cancer detection (ECD). This individual will play a pivotal role in shaping and executing the product strategy for high-impact diagnostics aimed at improving patient outcomes through earlier interventions. With a deep understanding of product development in the diagnostics space, the ideal candidate will lead cross-functional teams through all phases of product development—from feasibility through launch, growth, and obsolescence. This is a high-ownership role combining strategic vision and technical execution, requiring experience in the diagnostics or life sciences industry with a demonstrated ability to launch novel, clinically impactful products.

Primary Responsibilities

• Lead the product lifecycle for ECD diagnostics, from concept to commercialization, including product definition, planning, and delivery.
• Define and execute a strategic product roadmap aligned with clinical and market needs for early cancer detection.
• Translate complex clinical and scientific insights into clear product requirements in partnership with R&D, clinical affairs, software engineering, and regulatory teams.
• Lead Voice of Customer (VOC) initiatives, competitive analysis, and market research to ensure product differentiation and customer satisfaction.
• Define and monitor key product performance indicators (KPIs) such as sensitivity, specificity, and turnaround time; collaborate with cross-functional teams to drive continuous improvement.
• Own product development documentation, including user needs, product requirements, and risk assessments.
• Collaborate with Clinical and Regulatory Affairs to support study design, data analysis, and regulatory submissions.
• Partner with Marketing and Commercial teams to establish value propositions, go-to-market strategy, pricing models, and launch readiness.
• Develop financial models and business cases to support portfolio investment decisions and growth opportunities.
• Provide regular updates to senior leadership and stakeholders on product development progress, roadmap evolution, and strategic priorities.

Qualifications

• Bachelor’s degree in a life science, engineering, or relevant technical discipline required; Master’s or advanced degree preferred.
• Minimum 5+ years of experience in product management or development within the diagnostics, oncology, or medical device industries.
• Deep understanding of early cancer detection technologies and clinical workflows strongly preferred.
• Experience with regulated products, including IVDs or LDTs, and familiarity with FDA or CLIA regulatory pathways.
• Proven ability to manage complex, cross-functional product development efforts in a matrixed environment.

Knowledge, Skills, and Abilities

• Strategic thinker with strong executional focus and a track record of delivering impactful products.
• Exceptional ability to communicate scientific and technical information to both technical and non-technical audiences.
• Strong project and process management skills; detail-oriented with excellent organizational capabilities.
• Financial acumen for developing business cases and modeling product economics.
• Skilled in Microsoft Office and product management tools; experience with Agile development methodologies is a plus.
• Able to influence and align stakeholders across functions, from R&D to commercial.

Company Information

Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make a difference in people's lives by advancing the science of genetic testing.