[Remote] Cryo-FIB Application Scientist at Thermo Fisher Scientific

Tennessee, United States

Apply Now

Not SpecifiedCompensation

Senior (5 to 8 years)Experience Level

Full TimeJob Type

UnknownVisa

Life Sciences, Biotechnology, Biomedical ResearchIndustries

Requirements

Expertise in cryo-Electron Tomography (Cryo-ET) and Volume EM workflows
Experience with cryoFIB milling using plasma FIB (pFIB), including Arctis and Hydra Bio cryo-plasma-FIBs
Knowledge of sample preparation for cellular lamella and optimization methods
Familiarity with cryo-Transmission Electron Microscope (TEM) instruments like Krios
Experience with high pressure frozen cellular and tissue samples
Ability to work in laboratory settings with environmental conditions: cold rooms/freezers (-22°F/-6°C), loud noises, strong odors, hazardous/toxic materials, and PPE (safety glasses, gowning, gloves, lab coat, ear plugs)
Ability to collaborate with scientific community, train users (on-site and remotely), and conduct proof-of-concept experiments

Responsibilities

Develop pioneering methods and protocols for cryoFIB milling with plasma FIB (pFIB) in Cryo-ET and Volume EM workflows
Coordinate applications development for cryo-FIB projects with collaborators in a world-class cryo-imaging lab
Perform cryoFIB milling to prepare cellular lamella and optimize sample preparation methods for cryo-Electron Tomography on Krios TEM instruments
Develop methods and workflows for volume imaging of high pressure frozen cellular and tissue samples using cryo Auto Slice & View on pFIB dual beam systems
Develop and evaluate FIB milling and volume imaging strategies with plasma FIB on cells and tissues
Work with collaborators to train users (on-site and remotely) and implement proof-of-concept experiments with challenging samples
Support R&D, product development, marketing, and sales with applications expertise
Communicate new applications results at scientific workshops, conferences, and contribute to scientific publications
Serve as an expert for cryoEM sample preparation with plasma FIB instruments
Provide feedback to engineering and software development teams on system performance, new design features, hardware qualification

Skills

Key technologies and capabilities for this role

Cryo-FIBElectron MicroscopyBiological ImagingStructural Cell BiologyProtein Complexes ImagingVolume Electron MicroscopyCryo-EM WorkflowsLaboratory TechniquesHazardous Materials Handling

Questions & Answers

Common questions about this position

Is this a remote position or does it require on-site work?

This is an on-site position embedded in the Center of Excellence for Structural Cell Biology at St. Jude Children's Research Hospital in Memphis, Tennessee.

What are the key responsibilities of this role?

The role involves developing methods and protocols for cryoFIB milling with plasma FIB (pFIB) in Cryo-ET workflows, optimizing sample preparation for cellular lamella, performing cryo-Electron Tomography on Krios TEM instruments, and developing workflows for volume imaging of high pressure frozen samples.

What is the work schedule and environment like?

This is a full-time position with a standard Monday-Friday schedule in a laboratory setting involving cold rooms, loud noises, strong odors, hazardous materials, and PPE requirements.

What is the company culture like at Thermo Fisher Scientific?

The company emphasizes diversity and inclusion as core to its identity, fostering an environment where colleagues can share diverse perspectives, feel they belong, and do their best work while making a positive global impact.

What kind of experience makes a strong candidate for this role?

Strong candidates will have expertise in cryo-FIB milling, plasma FIB (pFIB), cryo-Electron Tomography (Cryo-ET), sample preparation for cellular lamella, and volume EM workflows, particularly with instruments like Arctis, Hydra Bio cryo-plasma-FIBs, and Krios cryo-TEM.

Thermo Fisher Scientific

Provides life sciences products and services

About Thermo Fisher Scientific

Thermo Fisher Scientific offers a variety of products and services that support scientific research and healthcare, including laboratory equipment, reagents, and software solutions. Their products are used in applications like protein biology, real-time PCR, and sequencing, serving clients such as academic institutions and pharmaceutical companies. Unlike competitors, Thermo Fisher emphasizes customer support and education, helping clients optimize their experiments. The company's goal is to be a leading provider of life sciences solutions that contribute to a healthier and safer world.

Waltham, MassachusettsHeadquarters

1956Year Founded

$17MTotal Funding

IPOCompany Stage

Biotechnology, HealthcareIndustries

10,001+Employees

Risks

Increased competition in single-use bioprocessing may impact market share.

Sale of anatomical pathology business could create a temporary product gap.

Investment in miDiagnostics may face regulatory challenges affecting returns.

Differentiation

Thermo Fisher offers a comprehensive range of life sciences products and services.

Their well-known brands include Thermo Scientific, Applied Biosystems, and Invitrogen.

They provide strong customer support and educational resources to optimize client workflows.

Upsides

Expansion of biologics production facility enhances capacity for precision biologics monitoring.

Investment in miDiagnostics aligns with demand for rapid diagnostic solutions in BioPharma.

Collaboration with Mainz Biomed positions them in the growing cancer detection market.

Land your dream remote job 3x faster with AI

Try Jobo Free