Senior/Staff Scientist, Chemistry at Glyphic Biotechnologies

Berkeley, California, United States

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$120,000 – $183,000Compensation

Senior (5 to 8 years)Experience Level

Full TimeJob Type

UnknownVisa

BiotechnologyIndustries

Requirements

PhD in chemistry, organic chemistry, or related field
5+ years of relevant experience in an industrial or startup setting
Strong background in nucleic acid & protein chemistry, bioconjugation, and analytical instrumentation
Comprehensive knowledge in bioconjugation and biorthogonal conjugation methods and techniques
Competence in peptide C-terminal conjugation chemistry
Experience with nucleic acid and peptide synthesis, natural and synthetic analogs
Experience in multi-step, small-scale organic synthesis, particularly from complex biological matrices or samples
Experience with HPLC, LC/MS, NMR, FTIR, UV/VIS, CE
Proficiency in scalable surface chemistry methods and techniques for flow cells and/or solid supports

Responsibilities

Design, develop, and optimize high throughput chemical reagent evaluation for single molecule protein sequencing, ensuring high sensitivity, specificity, and reproducibility
Synthesize assay specific reagents and materials for the proteome sequencing platform
Develop and/or validate peptide sample preparation schemes, such as C-terminal conjugation and amino acid sidechain derivatization
Collaborate with cross-functional teams to problem solve and integrate novel solutions into the assay workflow
Analyze complex experimental data, generate detailed reports, and provide actionable insights to guide further development
Utilize statistical methods and data visualization tools to interpret assay performance and ensure rigorous quality control
Prepare and maintain comprehensive documentation of experimental protocols, standard operating procedures (SOPs), and results
Drive innovation in reagent and compound synthesis and design and contribute to intellectual property development

Skills

Key technologies and capabilities for this role

BioconjugationBiorthogonal ConjugationPeptide SynthesisNucleic Acid SynthesisOrganic SynthesisHPLCLC/MSNMRFTIRUV/VISCESurface Chemistry

Questions & Answers

Common questions about this position

What is the salary range for this Senior/Staff Scientist position?

The salary range is $120K - $183K.

Is this role remote or does it require on-site work?

This information is not specified in the job description.

What are the key skills required for this Scientist role?

Key requirements include comprehensive knowledge in bioconjugation and biorthogonal conjugation, competence in peptide C-terminal conjugation chemistry, experience with nucleic acid and peptide synthesis, analytical skills in HPLC, LC/MS, NMR, FTIR, UV/VIS, CE, and proficiency in scalable surface chemistry methods.

What is the company culture like at Glyphic Biotechnologies?

The role involves working with a cross-disciplinary team to deliver consistent results and accelerate development, collaborating with cross-functional teams to problem solve and integrate novel solutions.

What makes a strong candidate for this position?

A strong candidate holds a PhD in chemistry, organic chemistry, or related field with 5+ years of relevant experience in an industrial or startup setting, plus expertise in bioconjugation, peptide chemistry, nucleic acid synthesis, and analytical techniques like HPLC and LC/MS.

Glyphic Biotechnologies

Develops next-generation protein sequencing platform

About Glyphic Biotechnologies

Glyphic Biotechnologies focuses on advancing the field of proteomics by developing a unique protein sequencing platform. This platform enables researchers to analyze proteins in detail, which helps them understand biological processes and diseases better. The technology works by providing advanced sequencing services that allow for in-depth study of protein structures and functions. Unlike other companies in the biotechnology sector, Glyphic Biotechnologies emphasizes a next-generation approach to protein sequencing, aiming to deliver insights that are not available through traditional methods. The company's goal is to enhance biological and medical research by providing tools that facilitate a deeper understanding of proteins and their roles in health and disease.

New York City, New YorkHeadquarters

2021Year Founded

$41.9MTotal Funding

EARLY_VCCompany Stage

Biotechnology, HealthcareIndustries

11-50Employees