Axsome Therapeutics Inc

Machine Learning Scientist II/Sr (Biomedical Images)

United States

$152,000 – $215,000Compensation
Junior (1 to 2 years), Senior (5 to 8 years)Experience Level
Full TimeJob Type
UnknownVisa
Biotechnology, Pharmaceuticals, Medical Imaging, Biomedical EngineeringIndustries

Machine Learning Scientist II or Senior

Salary: $152K - $215K Location Type: Remote Employment Type: Full-Time

Position Overview

Iambic Therapeutics is seeking a Machine Learning Scientist II or Senior to enhance our Enchant platform with clinically relevant imaging. The successful candidate will design and build models that learn from medical images and integrate them with multimodal biomedical data to advance drug discovery and clinical decision-making.

Key Responsibilities

  • Evaluate, adapt, and integrate pre-trained computer-vision models (e.g., Vision Transformers, vector-quantized encoders) into Enchant's existing modalities.
  • Locate and curate clinical imaging datasets (radiology, pathology, microscopy, etc.) and establish clear benchmarks for model performance.
  • Build reliable data pipelines for large image collections, encompassing ingestion, preprocessing, augmentation, and storage.
  • Convert research prototypes into production services on multi-GPU/HPC infrastructure and ensure their ongoing maintenance.
  • Collaborate with discovery, pre-clinical, and clinical teams to translate image insights into experimental and trial strategies.
  • Share results through code, documentation, and internal presentations; mentor colleagues in vision and multimodal ML.

Required Qualifications

  • PhD with 3+ years of industry experience OR MS with 5+ years of industry experience in Computer Vision, Machine Learning, Biomedical Engineering, or a related field.
  • Solid experience with deep learning for images, including self-supervised pre-training, Vision Transformers, or vector quantization methods.
  • Hands-on experience with large medical or scientific imaging datasets and establishing evaluation tasks and metrics.
  • Proficiency in PyTorch or JAX and experience running distributed training on GPUs or cloud HPC resources.
  • Strong software engineering practices: version control, testing, continuous integration, code review, and containerization.
  • Clear communication skills and the ability to work effectively in cross-disciplinary teams.

Preferred Qualifications

  • Familiarity with multimodal transformers.
  • Experience aligning image embeddings with molecular or clinical endpoints.
  • Contributions to open-source computer-vision or ML projects.

About Iambic Therapeutics

Iambic is a clinical-stage life-science and technology company dedicated to developing novel medicines through its AI-driven discovery and development platform. Founded in 2020 and based in San Diego, Iambic has assembled a world-class team of pioneering AI experts and experienced drug hunters. The Iambic platform has demonstrated the ability to deliver new drug candidates to human clinical trials with unprecedented speed across multiple target classes and mechanisms of action. Iambic is advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and through partnerships, to address urgent unmet patient needs.

Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.

Mission & Core Values

Our mission is to deliver better medicines through innovations in AI-based discovery technologies. The culture and work at Iambic Therapeutics are profoundly strengthened by the diversity of our people and our differences in background, culture, national origin, religion, sexual orientation, and life experiences. We are committed to building an inclusive environment where a diverse group of talented humans work together to discover therapeutics and create technologies.

Pay and Benefits

We offer industry-leading competitive pay, company-paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation. Our team enjoys a brand-new, state-of-the-art facility in beautiful San Diego, featuring an on-site gym, dining, and easy access to great living and recreational areas.

Skills

Computer Vision
Deep Learning
Vision Transformers
Vector Quantization
PyTorch
JAX
Distributed GPU Training
Medical Imaging
Data Pipelines
Model Deployment
Multimodal ML

Axsome Therapeutics Inc

Develops therapies for CNS disorders

About Axsome Therapeutics Inc

Axsome Therapeutics develops therapies for central nervous system (CNS) disorders, focusing on conditions like major depressive disorder, treatment-resistant depression, and Alzheimer's agitation. Their main product, AXS-05, is an oral medication that works by blocking NMDA receptors in the brain, which helps regulate mood. This drug has shown positive results in clinical trials and has received special FDA status to speed up its approval process. Unlike many competitors, Axsome emphasizes addressing unmet medical needs in CNS disorders and aims to improve patient outcomes through rigorous research and development. The company's goal is to bring effective treatments to market, enhancing the quality of life for patients suffering from these conditions.

New York City, New YorkHeadquarters
2012Year Founded
$430.7MTotal Funding
IPOCompany Stage
Biotechnology, HealthcareIndustries
201-500Employees

Benefits

Performance Bonus
Company Equity

Risks

Increased competition from companies like Compass Pathways in the CNS market.
Potential delays in AXS-07 launch amid growing market anticipation.
Departure of key personnel like Lori Englebert may impact strategic direction.

Differentiation

Axsome focuses on CNS disorders with limited current treatment options.
AXS-05, an NMDA receptor antagonist, targets major depressive disorder and treatment-resistant depression.
Axsome's balanced portfolio includes both clinical and research stage products.

Upsides

FDA's fast-tracking of CNS treatments could expedite Axsome's drug approvals.
Increased investment in CNS R&D drives innovation, benefiting Axsome's pipeline.
Growing personalized medicine trend offers Axsome opportunities for tailored therapies.

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