Head of Biotherapeutics (Sr. Director or VP Level) at Manifold Bio

Boston, Massachusetts, United States

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Not SpecifiedCompensation

Expert & Leadership (9+ years)Experience Level

Full TimeJob Type

UnknownVisa

BiotechnologyIndustries

Requirements

Experience taking multiple molecules through IND and into the clinic
Deep understanding of protein production techniques, including mammalian cell culture and purification/characterization approaches
Expertise in novel biotherapeutic modalities, across a range of formats
Extensive experience leading cross-functional teams
Experience with complex biologics (e.g. multispecifics)
Preferred Qualifications
Experience with drug development in neuroscience
Experience liaising with CDMOs through IND
Experience with generative AI models for protein design

Responsibilities

Leading internal protein sciences and protein engineering teams
Own strategy for early stage de-risking and optimization of lead molecules
Own strategy for developability assessment
Work with internal and external team members to ensure cost-effective and timely drug manufacture
Build internal expertise on cutting-edge protein engineering techniques
Guide prioritization for internal protein generation efforts, balancing between screening and lead characterization
Build an R&D-to-development pipeline for lead candidates
Utilize state of the art techniques to drive the development of best-in-class therapeutic candidates
Stay up to speed on cutting edge research and industry standards for protein therapeutics

Skills

Key technologies and capabilities for this role

Protein EngineeringBiologics ManufacturingCMCINDHigh-Throughput ScreeningProtein ProductionComputational DesignAntibody Engineering

Questions & Answers

Common questions about this position

What is the salary for the Head of Biotherapeutics position?

This information is not specified in the job description.

Is this role remote or does it require working in an office?

This information is not specified in the job description.

What are the key qualifications required for this role?

Candidates must have experience taking multiple molecules through IND and into the clinic, along with a deep understanding of protein production techniques including mammalian cell culture and purification/characterization. Extensive protein engineering experience across diverse formats and modalities is also essential.

What is the team structure like at Manifold Bio?

The role involves leading internal protein sciences and protein engineering teams, working with a world-class team of protein engineers, biologists, and computational scientists.

What makes a strong candidate for the Head of Biotherapeutics role?

A strong candidate will have extensive experience in protein engineering across diverse formats, deep knowledge of protein production for high-throughput screening, and proven success taking multiple biologics through IND-enabling studies.

Manifold Bio

Designs precision biologics using in vivo methods

About Manifold Bio

Manifold Bio specializes in creating precision biologics for the pharmaceutical industry, focusing on drug design and development. Their main product is an in vivo drug design platform, which allows for testing drugs within living organisms rather than in laboratory settings. This platform utilizes mCodes™ technology, a unique protein barcoding system that enables the simultaneous study of multiple proteins in one experiment, making it particularly effective for complex biologics. Unlike other companies, Manifold Bio's approach to drug design is distinct because it integrates in vivo testing with advanced protein multiplexing capabilities. The company's goal is to expand their platform and collaborate with other pharmaceutical companies to develop new therapeutics.

Boston, MassachusettsHeadquarters

2020Year Founded

$58.8MTotal Funding

SERIES_ACompany Stage

Biotechnology, HealthcareIndustries

11-50Employees