Bioinformatician

Position Overview

• Location Type: Remote USA
• Job Type: Full-time
• Salary: $101,800 - $127,300 USD

Natera™ is seeking a Bioinformatician with immunology experience to join a multidisciplinary team developing leading-edge genomics analysis tools to understand the immune system's response to cancer. This self-motivated, detail-oriented individual will join the Therapeutics and Innovations group and will be responsible for developing and applying bioinformatics methods to immuno-oncology clinical datasets, creating descriptive summary statistics and data visualizations, and technical reports.

Requirements

• Great understanding of immunology and human genetics (understanding of oncology is preferred).
• Experience analyzing genomic sequencing data from Illumina platforms.
• Experience analyzing long-read nucleic acid datasets such as PacBio or Oxford Nanopore.
• Experience analyzing high-throughput RNA-seq data.
• Familiarity with using and scripting in UNIX shell (e.g., Bash).
• Strong programming skills in common bioinformatics scripting languages (e.g., Python, R).
• Ability to collaborate and communicate with other scientists, researchers, and clinicians.
• Demonstrated project management skills and ability to produce readable, reproducible, and documented code (e.g., Jupyter, R markdown, etc.).
• Strong team-oriented work ethic with open, honest, and considerate communication skills.
• Immune repertoire analysis experience is a plus (e.g., Immcantation, MiXCR, TRUST4, immunarch, etc.).
• Experience writing SQL queries for data retrieval is required is a plus.
• Exposure to cancer genomics somatic variant calling is a plus.
• Experience working with large external data sources such as IEDB, iReceptor, VDJdb, and others is a plus.

Responsibilities

• With the assistance of a multidisciplinary team, develop or enhance computational tools to predict antigenic somatic variants.
• Assist bioinformaticians and data scientists in developing approaches to gain better understanding of T-cell receptor binding to MHC-peptide complexes.
• Use internal and external genomics data sources to understand how somatic and germline variation impacts the immune system’s response to cancer.
• Run and enhance established immune repertoire sequencing pipelines and workflows for NGS analysis in a clinical setting.
• Prototype, develop, document, deploy, and support novel clinical DNA and RNA sequencing analysis approaches for NGS analysis.
• Benchmark new tools for sequencing data analysis and propose improvements.
• Develop QC metrics, gold standard datasets and tools for systematically testing and evaluating the accuracy of newly developed assays and methods.
• Collaborate with technical teams in specifying requirements for tools to enhance workflow efficiency, turnaround times and robustness.
• Participate in internal research projects and external research collaborations.
• Assist in preparing text and figures for manuscripts and external presentations.
• Summarize results in written or oral reports for computational biologists, molecular biologists, clinicians, and internal researchers.

Education/Experience

• PhD degree in bioinformatics, computational biology, statistics, immunology, or a related field; OR
• MS degree with 3+ years of post-graduation experience in bioinformatics, biology, computational biology, statistics, immunology, or a related field.

Company Information

Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care.

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