Supervisor, Gene Manufacturing at Twist Bioscience

Portland, Oregon, United States

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Not SpecifiedCompensation

Mid-level (3 to 4 years), Senior (5 to 8 years)Experience Level

Full TimeJob Type

UnknownVisa

BiotechnologyIndustries

Requirements

A.S. or B.S. in Biology, Chemistry or Biochemistry
5 year minimum lab experience in manufacturing environment
Thorough experience operating liquid handlers such as Hamiltons and Tecans
Deep familiarity with molecular biology techniques such as PCR, cell-based cloning, DNA extraction and purification
Experience with sample tracking software such as LIMS/MES systems, especially when integrated with liquid-handling robots
Experience working within a ISO, GMP, LEAN manufacturing environment
Sharp data interpretation acumen
A track record of delivering process improvements
Laboratory management experience
Outstanding communication skills and emotional intelligence
Ability to stand for long periods of time while performing duties
Ability to work safely with chemicals and hazardous materials
Ability to lift up to 20 lbs
Ability to work outside of regular work hours/work a flexible shift as needed (SHIFT 2B: 7:00pm-7:30am Wednesday-Friday, Alt Saturday)
Knowledge of basic synthetic/molecular biology skills (PCR, vector production, cloning, mini prep, DNA analysis, sequencing, packaging)
Knowledge of good laboratory practices (GLPs) and familiarity working in GMP or ISO rated production

Responsibilities

Manufacture and analysis of custom gene products across Twist Bioscience’s proprietary workflow
Perform, train and/or oversee production staff on basic molecular biology workflows in a highly automated, high-throughput manner
Act as the main point of contact for shift operators
Assure staff is working according to the plan of record, provide guidance, make decisions on priorities and troubleshooting
Lead the pass down of information between shifts
Manufacture high-quality custom gene products in a high throughput MFG molecular biology lab according to established SOPs
Thoroughly maintain accurate and detailed documentation of all work performed, batch records
Operate basic as well as automated lab equipment for molecular biology workflow
Track quality metrics by both physical and functional test methods; initiate corrective actions necessary to bring production back to expected standards
Exercise keen observational skills to proactively identify production problems, then lead technical discussions to provide solutions, including issues involving lab techniques, protocols, processes and handling of product and equipment
Uphold standards as defined by the manufacturing process
Support continuous cost/process improvement initiatives
Promote and prioritize a safe work environment
Maintain and calibrate lab equipment
Lead shift pass-down efforts and prioritize work to be done
Take accountability for the shift when senior personnel are not on site
Act as advisor to meet schedules and/or resolve technical problems and provide production guidance to junior MFG personnel
Schedule staff
Review and verify production batch records and manufacturing documents
Write and submit incident reports, CAPAs, planned deviations etc
Follow regulatory and ISO 13485 requirements
Maintain and build 5S systems
Contribute to process improvement and documentation
Communicate effectively with peers and management

Skills

PCR

cloning

miniprep

DNA analysis

sequencing

vector production

packaging

SOPs

batch records

GLP

GMP

ISO

process improvement

Twist Bioscience

Produces synthetic DNA for biotechnology applications

About Twist Bioscience

Twist Bioscience specializes in creating synthetic DNA for applications in biotechnology, pharmaceuticals, and research. Their proprietary platform allows for the quick and accurate production of DNA sequences, providing clients with products like genes, oligo pools, and variant libraries. The company stands out by offering high-quality DNA at competitive prices, making them a valuable partner for academic institutions and pharmaceutical companies. Twist Bioscience aims to support advancements in personalized medicine and biotechnology through their innovative DNA synthesis solutions.

South San Francisco, CaliforniaHeadquarters

2013Year Founded

$236.5MTotal Funding

IPOCompany Stage

Biotechnology, HealthcareIndustries

1,001-5,000Employees

Benefits

Health Insurance

Dental Insurance

Vision Insurance

Disability Insurance

Life Insurance

401(k) Retirement Plan

Risks

Increased competition from Ginkgo Bioworks may impact Twist's market share.

Dependency on AI technologies could pose integration and operational challenges.

New CIO appointment may lead to transitional challenges in IT strategy and operations.

Differentiation

Twist Bioscience uses a unique silicon-based DNA synthesis platform for precision and scale.

They offer high-quality DNA sequences at competitive prices, attracting diverse clients.

Their proprietary platform provides instant feedback on DNA sequence synthesis feasibility.

Upsides

Growing demand for synthetic DNA in personalized medicine boosts Twist's market potential.

Collaboration with Absci leverages AI to accelerate antibody discovery and drug development.

Synthetic biology market projected to grow at 28.8% CAGR, benefiting Twist's growth.

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