Sr. Mechanical Engineer at Alamar Biosciences

Fremont, California, United States

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Not SpecifiedCompensation

Senior (5 to 8 years)Experience Level

Full TimeJob Type

UnknownVisa

Biotechnology, Life SciencesIndustries

Requirements

Bachelor’s or Master’s degree in Mechanical Engineering, Mechatronics, or a related field
6+ years in mechanical engineering for biotech instrumentation, medical devices, or life sciences platforms (e.g., NGS sequencers, PCR analyzers, or protein detection systems), with expertise in both sustaining and developing complex electro-mechanical systems
Expert in 3D CAD modeling (SolidWorks preferred)
Experience designing precision gantry systems (e.g., XY/XYZ): linear guides, belts/lead screws/ball screws, stepper/BLDC drives, kinematics and backlash management, alignment/calibration methods, tolerance analysis, and safety/interlocks
Expertise in mechanisms, materials, GD&T, and tolerance analysis
Proficiency in structured problem-solving, verification/validation (V&V), and risk management processes
Excellent analytical, problem-solving, written, and verbal communication skills
Ability to collaborate across disciplines and present technical concepts clearly to non-experts
Proactive, adaptable, and thrive in a fast-paced startup environment with a strong sense of ownership
Preferred: Demonstrated ownership from concept → V&V → transfer to manufacturing → sustaining

Responsibilities

Sustaining Engineering: Own mechanical reliability improvement projects (life testing, FMEA updates, failure analysis). Drive design changes via ECOs and partner with Manufacturing to validate fixes
Next-Generation Development: Build and bring-up alpha/beta prototypes; define verification methods (gage R&R, test fixtures, acceptance criteria) and analyze results to iterate designs
Partner with Systems/Software/Vendor to integrate sensors/actuators; define interfaces, alignment/adjustment schemes, and calibration methods
CAD: Develop and maintain 3D CAD models and assemblies using SolidWorks. Release production drawings with full GD&T and critical-to-quality callouts
Hands-On Execution: Perform assembly, testing, and debugging in lab settings using diagnostic tools and equipment to verify functionality. Develop and validate testing or manufacturing fixtures
Documentation: Own BOMs, CAD, and production drawings with full GD&T; ensure change traceability, serviceability, backwards compatibility and smooth change management with CM
Manufacturing Integration: Identify advanced materials, suppliers and processes (e.g., injection molding, CNC machining, sheet metal fabrication) to improve cost-efficiency and system robustness

Skills

Key technologies and capabilities for this role

CAD3D CADFMEAFailure AnalysisLife TestingPrototypingGage R&RTest FixturesSensorsActuatorsMechanical DesignECOsManufacturing Validation

Questions & Answers

Common questions about this position

What experience is required for the Senior Mechanical Engineer role?

Candidates need 6+ years in mechanical engineering for biotech instrumentation, medical devices, or life sciences platforms such as NGS sequencers, PCR analyzers, or protein detection systems, along with a Bachelor’s or Master’s degree in Mechanical Engineering, Mechatronics, or a related field.

What key technical skills are needed for this position?

Proficiency in SolidWorks for 3D CAD models and assemblies, releasing production drawings with GD&T, hands-on assembly/testing/debugging, and knowledge of manufacturing processes like injection molding, CNC machining, and sheet metal fabrication are required.

What is the company culture like at Alamar Biosciences?

The culture rewards accountability and cross-functional teamwork, seeking collaborative, driven, intellectually curious people committed to solving complex challenges in a fast-paced startup environment to accelerate their mission.

Is this a remote position or does it require on-site work?

This information is not specified in the job description.

What is the salary or compensation for this role?

This information is not specified in the job description.

Alamar Biosciences

Develops technology for protein detection and measurement

About Alamar Biosciences

Alamar Biosciences focuses on the study of proteins, known as proteomics, to enhance disease detection and treatment. The company has created NULISA™, a technology that can detect and measure proteins in the human body with high sensitivity and a wide range. This allows researchers and clinicians to profile clinically relevant protein biomarkers, which are essential for developing new diagnostic tests and treatments for various diseases. Alamar's ARGO™ system complements NULISA™ by providing a fully automated, high-throughput platform for precision proteomics. Unlike competitors, Alamar's technology simplifies the process, reducing the need for extensive technical expertise, making it more accessible to clients. The goal of Alamar Biosciences is to improve our understanding of proteins in health and disease, ultimately leading to better early detection and treatment options.

Hayward, CaliforniaHeadquarters

2018Year Founded

$225.7MTotal Funding

GRANTCompany Stage

Biotechnology, HealthcareIndustries

51-200Employees

Benefits

401(k) Company Match

401(k) Retirement Plan

Performance Bonus

Company Equity

Risks

Increased competition from Olink and SomaLogic may impact Alamar's market share.

Scaling production in Europe and APAC could strain resources and affect quality.

Regulatory hurdles in new regions may delay product launches and affect revenue.

Differentiation

Alamar's NULISA™ technology offers unprecedented sensitivity in protein detection.

The ARGO™ system automates high-throughput proteomics, reducing the need for technical expertise.

Alamar's focus on early disease detection sets it apart in the biotechnology field.

Upsides

ISO 13485:2016 certification boosts Alamar's credibility in the medical device industry.

European expansion with Milan headquarters enhances market reach and client service.

$10M investment accelerates Alzheimer's diagnostics development, strengthening Alamar's market position.

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