Scientist, Antibody Discovery & Characterization at Ginkgo Bioworks

Massachusetts, United States

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Not SpecifiedCompensation

Mid-level (3 to 4 years), Senior (5 to 8 years)Experience Level

Full TimeJob Type

UnknownVisa

Biotechnology, PharmaceuticalsIndustries

Requirements

Ph.D. in Biochemistry, Immunology, Bioengineering, or a related field with 0-2 years of industry/academic experience (or M.S. with 6+ years or B.S. with 8+ years of relevant experience)
Deep expertise in the design, engineering, expression, and characterization of complex protein formats, with a demonstrated track record working with bispecific or multi-specific antibodies
Demonstrated proficiency in antibody developability assessment using multiple biophysical techniques (e.g., DSF, DLS, SEC, HIC, AC-SINS, Polyreactivity)
Extensive hands-on expertise with SPR (e.g., Biacore) or BLI (e.g., Octet) for quantitative analysis of complex binding interactions, such as simultaneous binding of bispecifics
Proven ability to independently lead projects and contribute to experimental design
Excellent communication skills and the ability to thrive in a highly collaborative, multidisciplinary environment

Responsibilities

Lead the design and engineering of novel antibody formats, including bispecific and multi-specific constructs, to optimize for function and developability
Develop and execute workflows for the production (transfection, expression) and purification of complex antibody formats
Design and implement a wide range of biophysical and functional assays to evaluate antibody binding, stability, and activity, with a focus on challenges unique to bi/multi-specifics, VHHs, and scFvs
Develop methods for developability assessments for novel antibody formats (such as bi/multi-specifics), as well as binding kinetics (SPR/BLI), and functional cell-based assays
Provide technical leadership and hands-on expertise to troubleshoot expression, purification, and analytical challenges associated with novel formats
Contribute to scientific strategy, innovation, and the continuous improvement of our developability assessment platform
Mentor and guide junior scientists
Author technical reports, SOPs, and present findings to internal leadership and external customers

Skills

Antibody Engineering

Protein Engineering

Biophysical Assays

Functional Assays

SPR

BLI

Cell-Based Assays

Workflow Development

Troubleshooting

Technical Leadership

Scientific Strategy

Mentoring

Ginkgo Bioworks

Programs cells to produce custom organisms

About Ginkgo Bioworks

Ginkgo Bioworks specializes in biotechnology by using advanced cell programming technology to create custom organisms that can produce various products, including food ingredients, fragrances, and therapeutics. Their platform allows them to design and grow these organisms, effectively turning cells into small factories that generate valuable compounds. Ginkgo collaborates with a wide range of clients, such as companies in the food and beverage sector, pharmaceuticals, agriculture, and biosecurity, to develop tailored biological solutions. This collaborative approach sets them apart from competitors, as they focus on partnerships to drive innovation and ensure a steady revenue stream through service fees, milestone payments, and royalties. The company's goal is to be a leader in the biotechnology field by providing custom solutions that meet the specific needs of their partners.

Boston, MassachusettsHeadquarters

2009Year Founded

$1,524.7MTotal Funding

IPOCompany Stage

Food & Agriculture, Biotechnology, HealthcareIndustries

1,001-5,000Employees

Benefits

Unlimited paid time off

Comprehensive health and parental leave benefits

Flexible work options

Commuter benefits

State-of-the-art labs, work spaces, and conference rooms

Competitive 401K contribution

Risks

Competition from Phytolon threatens Ginkgo's market share in food ingredients.

Lesaffre's acquisition of Altar may intensify competition in biotechnology.

Fluctuating fertilizer prices could impact Ginkgo's agricultural projects.

Differentiation

Ginkgo Bioworks leverages advanced cell programming to create custom organisms for diverse industries.

The company collaborates with industry leaders like Moderna and Cronos Group for innovative solutions.

Ginkgo's platform enables the design of organisms for food, pharmaceuticals, and biosecurity.

Upsides

Partnership with Carnegie Mellon boosts Ginkgo's presence in bioelectronic disease treatment.

Acquisition of StrideBio's assets expands Ginkgo's gene therapy capabilities.

Collaboration with NOVUS International enhances sustainable solutions in animal agriculture.

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