Process Development Engineer - Early Phase Peptide/Oligonucleotide at Eli Lilly and Company

Indianapolis, Indiana, United States

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Not SpecifiedCompensation

Mid-level (3 to 4 years)Experience Level

Full TimeJob Type

UnknownVisa

Pharmaceuticals, BiotechnologyIndustries

Requirements

Background in chemical engineering
Experience or knowledge in synthetic molecule unit operation design, solid phase and liquid phase peptide and oligonucleotide synthesis, and downstream purification and isolation
Proficiency in data-rich experimentation techniques
Ability to apply fundamental engineering principles and equipment knowledge for process scale-up
Skills in numerical engineering modeling tools for reaction kinetics, mechanisms, and process separations
Capability to design effective process and equipment flow strategies and select suitable equipment

Responsibilities

Generate process design and unit operation knowledge based on engineering principles for small molecules, peptides, oligonucleotides, and other emerging therapeutic modalities
Ensure successful scale-up of processes through fundamental engineering principles and equipment knowledge
Design and execute laboratory experiments related to solid phase and liquid phase peptide and oligonucleotide synthesis, and downstream purification and isolation
Develop drug substance and manufacturing technologies
Engage in generating creative solutions for improving existing processes and the creation of novel ones
Transfer process technical information to internal pilot plant
Provide technical oversight for pilot scale GMP manufacturing activities
Author and maintain documentation such as laboratory notebooks and technical reports
Apply fundamental engineering and business principles to design and characterize synthetic processes
Use numerical engineering modeling tools to characterize reaction kinetics, reaction mechanisms, and process separations
Design effective and efficient process and equipment flow strategies, ensuring equipment is selected which is suitable and appropriate

Skills

Chemical Engineering

Process Development

Peptide Synthesis

Oligonucleotide Synthesis

API Development

Scale-up

Synthetic Chemistry

Drug Substance Manufacturing

Eli Lilly and Company

Develops and delivers prescription medicines globally

About Eli Lilly and Company

Eli Lilly and Company is a global pharmaceutical company that focuses on discovering, developing, and delivering medicines to improve health. The company has a long history of scientific achievements, including the creation of insulin, the first life-saving treatment for diabetes. Lilly's operations involve extensive research and development to create new medications and enhance existing ones, ensuring they are safe and effective. Their products are primarily prescription medicines sold to healthcare providers for various medical conditions, including diabetes, cancer, and pain management. What sets Lilly apart from its competitors is its strong commitment to ethical practices and the protection of its products from counterfeiting. The company's goal is to enhance lives through innovative medical solutions while maintaining high standards of quality and ethics.

Indianapolis, IndianaHeadquarters

1876Year Founded

$1,180.1MTotal Funding

IPOCompany Stage

Biotechnology, HealthcareIndustries

10,001+Employees

Risks

Competition from Novo Nordisk's Ozempic may impact tirzepatide's market share.

Potential construction delays in Indiana could affect GLP-1 drug production timelines.

Regulatory challenges may hinder Kisunla's expansion in new Alzheimer's markets.

Differentiation

Eli Lilly's rich history includes the first life-saving insulin treatment.

Lilly's strategic partnerships enhance its position in neurodegenerative disease treatments.

FDA approval of Zepbound opens new therapeutic markets for sleep disorder treatments.

Upsides

Lilly's $9 billion complex in Indiana boosts GLP-1 drug production capacity.

Kisunla's approval in China expands Lilly's Alzheimer's treatment market in Asia.

Collaboration with EVA Pharma enhances Lilly's reputation as socially responsible.

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