Principal Scientist, Medical Physicist at Bristol-Myers Squibb

San Diego, California, United States

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Not SpecifiedCompensation

Senior (5 to 8 years), Expert & Leadership (9+ years)Experience Level

Full TimeJob Type

UnknownVisa

Biotechnology, Pharmaceuticals, Oncology, RadiopharmaceuticalsIndustries

Requirements

Advanced degree in Medical Physics or Engineering (PhD preferred) with didactic training in RPT biodistribution, kinetics and dose modelling
Minimum of 6 years of experience in molecular imaging and RPT dose modelling research, or 3 years of extensive RPT-specific publications (10+)
Experience with radiopharmaceuticals as therapeutics in oncology and experience with alpha-emitters strongly desired
Subject Matter Expert in mathematical pharmacokinetic modeling and its application in radiopharmaceutical research and development
Technical skills with dosimetry software, coding and simulation/modeling/statistical tools (e.g. 3D-RD-S, MIM, MIRDcalc, OLINDA, Torch, GATE, SIMIND, SAAM II, SimBiology, Python, Matlab)

Responsibilities

Work closely with Radiation Biophysics/Medical Physics to support all aspects of internal dosimetry analysis in discovery and development of radiopharmaceutical imaging and therapeutic agents
Work closely with Discovery to design experiments and perform dosimetric data analysis from imaging modalities like PET (positron emission tomography) and SPECT (single-photon emission computed tomography) to assess drug uptake and distribution
Identify and advise best practices and standardization processes for image data quality control in preclinical research, aligned with current guidance in literature
Analyze preclinical and clinical imaging data to advance the translation of animal-to-human dose projection
Explore new technologies and modelling approaches to improve the development of radiopharmaceuticals, such as novel radioisotopes including alpha-emitters
Contribute to the advancement of medical physics knowledge in the field of radiopharmaceuticals
Provide technical support, training and problem-solving solutions to cross-functional teams as needed
Lead translational dosimetry analysis such as physiologically based pharmacokinetics or compartmentalization modelling
Provide technical support including dosimetry calculations and work in collaboration with internal stakeholders as well as external vendors and experts

Skills

Medical Physics

Radiopharmaceuticals

Dosimetry

Dose Modeling

Physiologically Based Pharmacokinetics

PBPK

Compartmental Modeling

Pharmacokinetics

In Vitro Studies

In Vivo Studies

Clinical Dosimetry

Bristol-Myers Squibb

Develops and delivers biopharmaceutical medicines

About Bristol-Myers Squibb

Bristol Myers Squibb (BMS) develops and delivers medicines aimed at treating serious diseases, focusing on areas like cancer, autoimmune diseases, and heart conditions. The company conducts extensive research and development to create new drugs, which are sold after receiving regulatory approval. BMS also produces generic drugs, offering affordable alternatives that meet the same quality standards as their branded counterparts. What sets BMS apart from competitors is its dual focus on both innovative and generic medicines, enhancing access to healthcare. The company's goal is to improve patient outcomes while maintaining a commitment to sustainability and corporate responsibility.

New York City, New YorkHeadquarters

1887Year Founded

$33,706.1MTotal Funding

IPOCompany Stage

Biotechnology, HealthcareIndustries

10,001+Employees

Benefits

Flexible Work Hours

Hybrid Work Options

Professional Development Budget

Risks

Increased competition in oncology from emerging biotech firms like ArsenalBio.

BMS's lawsuit over the 340B Drug Pricing Program may lead to regulatory challenges.

Rapid AI and digital tech evolution may pose integration challenges for BMS.

Differentiation

BMS focuses on innovative cancer treatments through collaborations like ArsenalBio for T cell therapies.

The company emphasizes digital health technologies, enhancing clinical trial management and patient engagement.

BMS offers both innovative and generic medicines, increasing affordable healthcare solutions.

Upsides

BMS's partnership with Medidata enhances clinical research processes and patient outcomes.

The collaboration with AI Proteins advances novel miniprotein-based therapeutics, expanding therapeutic modalities.

BMS's global license agreement with BioArctic expands its portfolio in neurodegenerative diseases.

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