Manufacturing Lead - IgG Production at Twist Bioscience

Portland, Oregon, United States

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Not SpecifiedCompensation

Senior (5 to 8 years)Experience Level

Full TimeJob Type

UnknownVisa

Biotechnology, ManufacturingIndustries

Requirements

Bachelors/Associates degree in biology, chemistry, biochemistry (preferred, but will consider relevant laboratory experience)
Familiarity or prior experience in a manufacturing environment
Good written and verbal communication skills
Attention to detail
Good computer skills, comfort using computers for manufacturing (experience with Excel, Word, Jira/Confluence, web-based or similar programs)
Ability to work in a controlled laboratory environment
Ability to stand for long periods of time
Ability to work safely with chemicals and hazardous materials
Ability to lift up to 20 lbs
Flexibility to work outside regular hours or flex shifts (including possible shifts: Sunday-Wednesday or Wednesday-Saturday, 7AM-7PM/7:30PM, 12h days, 3/4 day alt work week with 1 weekend day)

Responsibilities

Assist production supervisor and guide work of manufacturing associates on the floor
Troubleshoot manufacturing processes and instrumentation
Take responsibility for daily operations when supervisor is unavailable (equipment maintenance, fulfill production requests, retain review)
Maintain daily operations with or without supervisor
Review time-sensitive materials and calendar events
Oversee material inventory and waste management for the shift
Monitor flow of intermediate products through Manufacturing Execution System (MES) and notify supervisor of discrepancies
Review JIRA tickets with supervisor to create action items
Enforce checklists and auditing activities in the production process
Train new laboratory manufacturing associates
Work in the laboratory and perform any process tasks
Manufacture high-quality custom oligo-containing products according to SOPs
Operate laboratory equipment and liquid handling robots (e.g., Hamilton Stars, centrifuges, sealers, thermocyclers, spectrometers, Illumina Next-Gen sequencers)
Use molecular and cell biology processes/techniques (e.g., PCR, DNA quantitation, purification, cloning)
Maintain thorough, accurate, detailed documentation using templates and applications
Update and write work instructions and documentation
Work independently and safely
Pay attention to detail for consistent results
Perform troubleshooting and handle process deviations
Analyze data from manufacturing steps and decide/recommend actions
Follow lean manufacturing, ISO, and GMP practices
Maintain production schedule, troubleshoot, guide shift associates, and perform manufacturing tasks (e.g., operate equipment, documentation, lab cleaning/restocking, good lab techniques)

Skills

Liquid Handling Robots

Laboratory Equipment

SOPs

Batch Records

Troubleshooting

Equipment Maintenance

Inventory Management

Waste Management

MES

Lab Techniques

Twist Bioscience

Produces synthetic DNA for biotechnology applications

About Twist Bioscience

Twist Bioscience specializes in creating synthetic DNA for applications in biotechnology, pharmaceuticals, and research. Their proprietary platform allows for the quick and accurate production of DNA sequences, providing clients with products like genes, oligo pools, and variant libraries. The company stands out by offering high-quality DNA at competitive prices, making them a valuable partner for academic institutions and pharmaceutical companies. Twist Bioscience aims to support advancements in personalized medicine and biotechnology through their innovative DNA synthesis solutions.

South San Francisco, CaliforniaHeadquarters

2013Year Founded

$236.5MTotal Funding

IPOCompany Stage

Biotechnology, HealthcareIndustries

1,001-5,000Employees

Benefits

Health Insurance

Dental Insurance

Vision Insurance

Disability Insurance

Life Insurance

401(k) Retirement Plan

Risks

Increased competition from Ginkgo Bioworks may impact Twist's market share.

Dependency on AI technologies could pose integration and operational challenges.

New CIO appointment may lead to transitional challenges in IT strategy and operations.

Differentiation

Twist Bioscience uses a unique silicon-based DNA synthesis platform for precision and scale.

They offer high-quality DNA sequences at competitive prices, attracting diverse clients.

Their proprietary platform provides instant feedback on DNA sequence synthesis feasibility.

Upsides

Growing demand for synthetic DNA in personalized medicine boosts Twist's market potential.

Collaboration with Absci leverages AI to accelerate antibody discovery and drug development.

Synthetic biology market projected to grow at 28.8% CAGR, benefiting Twist's growth.

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