Director of Toxicology at Denali Therapeutics

South San Francisco, California, United States

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Not SpecifiedCompensation

Senior (5 to 8 years), Expert & Leadership (9+ years)Experience Level

Full TimeJob Type

UnknownVisa

Biotechnology, Pharmaceuticals, Neurodegenerative diseasesIndustries

Requirements

PhD in Toxicology, Biology, Pharmacology or related scientific discipline
15+ years of biotech/pharmaceutical drug discovery/development experience
Experience with biologics and oligonucleotides preferred
Strong scientific background and scientific aptitude
Excellent critical thinking and scientific skills
Ability to work effectively and collaboratively on cross-functional project teams, and demonstrated can-do attitude
Ability to work in a fast-paced environment
Excellent oral, presentation, and written communication skills

Responsibilities

Design and implement nonclinical toxicology programs and strategies to evaluate the safety of Denali's therapeutic candidates
Conduct and oversee non-GLP and GLP toxicology studies, ensuring adherence to regulatory standards
Analyze, interpret, and summarize toxicology data to support safety evaluations
Prepare and present safety data to internal project teams and senior management, contributing to informed decision-making
Assist in the preparation and authoring of regulatory documents related to nonclinical safety assessments
Ensure compliance with relevant regulatory guidelines and standards throughout all stages of toxicology studies
Work closely with colleagues in Research and Development, providing toxicology expertise to support cross-functional project teams
Participate in project meetings, offering insights and recommendations to advance safety assessment strategies
Support investigative efforts into mechanisms of toxicity and contribute to the development of safer therapeutic candidates
Assist in developing and implementing de-risking strategies for drug discovery and development projects

Skills

Key technologies and capabilities for this role

ToxicologyGLP studiesNon-GLP studiesSafety assessmentData analysisRegulatory documentsNonclinical safety

Questions & Answers

Common questions about this position

What is the salary range for the Director of Toxicology position?

The salary range is $204,000.00 to $258,667.00.

Is this a remote position or does it require working in an office?

This information is not specified in the job description.

What qualifications and skills are required for this role?

A PhD in Toxicology, Biology, Pharmacology or related scientific discipline is required, along with 15+ years of biotech/pharmaceutical drug discovery/development experience. Preferred experience includes biologics and oligonucleotides, strong scientific aptitude, critical thinking, collaboration skills, and excellent communication abilities.

What is the company culture like at Denali Therapeutics?

Denali emphasizes collaboration among leading scientists, industry experts, and investors, with a fast-paced environment, cross-functional teamwork, and a can-do attitude focused on scientific discovery and translational medicine for neurodegenerative diseases.

What makes a strong candidate for the Director of Toxicology role?

Strong candidates will have a PhD in a relevant field, 15+ years of biotech/pharma experience preferably with biologics and oligonucleotides, proven cross-functional collaboration, critical thinking, and excellent communication skills in a fast-paced setting.

Denali Therapeutics

Develops treatments for neurodegenerative diseases

About Denali Therapeutics

Denali Therapeutics focuses on finding and developing treatments for neurodegenerative diseases like Alzheimer's, Parkinson's, and ALS, which involve the gradual loss of nerve cells and can lead to serious physical and mental challenges. The company uses scientific research to understand the biological pathways that lead to these diseases, aiming to create drugs that target specific molecules in the body to treat them. Denali stands out from its competitors by combining its own research efforts with partnerships with other biotech firms and pharmaceutical companies, allowing it to share risks and access new technologies. The goal of Denali Therapeutics is to create effective treatments that improve the lives of patients suffering from these debilitating conditions.

South San Francisco, CaliforniaHeadquarters

2015Year Founded

$337.5MTotal Funding

IPOCompany Stage

Biotechnology, HealthcareIndustries

201-500Employees

Risks

Failure in ALS trials raises concerns about pipeline efficacy.

Increased competition in ALS treatment could impact market share.

Discontinuation of programs due to toxicities highlights potential development challenges.

Differentiation

Denali focuses on neurodegenerative diseases like Alzheimer's, Parkinson's, and ALS.

The company employs a science-driven approach to translational medicine and clinical development.

Denali leverages partnerships to access new technologies and spread financial risk.

Upsides

Denali's $500 million financing strengthens its financial position for pipeline advancement.

Partnership with Biogen could accelerate Parkinson's treatment development.

Focus on blood-brain barrier technology shows promise in treating lysosomal storage diseases.

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