Genesis Therapeutics

Technical Program Manager, Foundation Models (Staff / Principal)

New York, New York, United States

Not SpecifiedCompensation
Expert & Leadership (9+ years)Experience Level
Full TimeJob Type
UnknownVisa
Biotechnology, Artificial Intelligence, Drug DiscoveryIndustries

Technical Program Manager, Genesis AI

Employment Type: Full-time

About the Team

Join a world-class team at the forefront of AI and biochemistry. At Genesis Therapeutics, we’re a tight-knit team of proven deep learning researchers, software engineers, and drug discovery pioneers. Our shared mission is nothing short of revolutionary: to forge the next generation of AI foundation models that will unlock groundbreaking therapies for patients with severe diseases.

We don’t just apply machine learning to biology; we are conducting fundamental research at the intersection of machine learning, physics, and computational chemistry, pushing the boundaries of each field. You will work side-by-side with top multidisciplinary researchers to design and build generative foundation models at scale, having access to ample compute and large-scale simulations.

About the Role

As the Technical Program Manager for our Genesis AI team, you will be the operational leader orchestrating our most critical scientific and engineering initiatives. Your core mission is to drive the end-to-end delivery of our foundation models, ensuring our ambitious research roadmap translates into tangible, high-impact models that power our drug discovery platform.

You will be the nexus of our technical operations, creating the systems and processes that allow our research to scale effectively. You will ensure that our machine learning-led drug discovery programs are delivered on-time, on-scope, and aligned with scientific milestones. You will also help define and mature program processes, experiment governance, and model deployment pipelines that support our scientific mission. This means owning the strategic planning for our large-scale compute resources, implementing rigorous configuration management for reproducible research, and building the connective tissue between our AI researchers, platform engineers, and drug discovery teams.

You Will

  • Orchestrate the end-to-end delivery of our foundation models, translating strategic research goals into executable roadmaps and concrete milestones.
  • Manage our large-scale compute resources, partnering with research and engineering leads to ensure efficient scheduling and allocation for our most critical experiments.
  • Implement and oversee configuration management, establishing best practices for experiments, data, and models to ensure research is reproducible, traceable, and robust.
  • Drive cross-functional execution and mitigate risk by proactively identifying dependencies, anticipating blockers, and ensuring clear communication across all teams.
  • Design and mature our operational processes, creating lightweight, effective systems for experiment tracking, project documentation, and model release governance.
  • Act as a central communication hub, ensuring stakeholders from the AI team, the drug discovery labs, and leadership are aligned and informed.

You Are

  • A seasoned Technical Program Manager with significant experience managing complex ML, scientific computing, or biotech-focused projects.
  • A deeply technical partner whose background allows you to communicate fluently with ML researchers, platform engineers, and computational chemists.
  • An expert at navigating research-driven ambiguity, skilled at bringing structure, clarity, and focus to open-ended scientific projects, aligning priorities across science and engineering.
  • A master of execution and organization, able to translate high-level strategy into detailed plans and manage multiple concurrent workstreams flawlessly.
  • An exceptional communicator and collaborator who excels at building consensus and aligning technical and non-technical partners toward a common goal.
  • Passionate about advancing science through technology in high-impact, mission-driven work.
  • Inspired by our culture of intellectual curiosity and the shared belief that breakthroughs happen when diverse perspectives and minds unite.

Nice to Haves

  • A BS or higher in Computer Science, Computational Chemistry, BioEngineering or a related field.
  • Experience at

Skills

Technical Program Management
Foundation Models
AI
Machine Learning
Deep Learning
Drug Discovery
Scientific Initiatives
Engineering Initiatives
Research Roadmap
Generative Models
Large-scale Simulations
Compute Resources
Configuration Management
Model Deployment
Program Management
Experiment Governance
Platform Engineering

Genesis Therapeutics

AI-driven drug discovery for pharmaceuticals

About Genesis Therapeutics

Genesis Therapeutics accelerates the development of new medicines by using artificial intelligence in drug discovery. The company combines 3D spatial graph modeling and molecular simulation to identify potential drug candidates and explore new chemical spaces. Unlike its competitors, Genesis Therapeutics focuses on strategic partnerships with other biotech and pharmaceutical companies, generating revenue through upfront payments and future earnings based on drug success. The goal is to transform the drug discovery process and bring new therapies to market.

Burlingame, CaliforniaHeadquarters
2019Year Founded
$272.5MTotal Funding
SERIES_BCompany Stage
AI & Machine Learning, BiotechnologyIndustries
51-200Employees

Benefits

Competitive salary
Equity
Medical, dental, & vision insurance
401(k) program

Risks

Competition from AI-driven companies like Insilico Medicine and Exscientia is increasing.
Over-reliance on partnerships could lead to financial instability if drugs aren't successful.
Rapid AI advancements may render current models like GEMS obsolete without updates.

Differentiation

Genesis Therapeutics uses AI to accelerate drug discovery with 3D spatial graph modeling.
The GEMS platform integrates deep learning, molecular simulations, and generative AI for drug design.
Strategic partnerships with Eli Lilly and Gilead highlight Genesis' industry collaboration strength.

Upsides

Partnership with NVIDIA enhances GEMS platform for targeting undruggable diseases.
$224 million equity investment boosts research and development capabilities.
Recognition as a 'Fierce 15' company underscores AI's role in breakthrough therapeutics.

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