[Remote] Senior Scientist, Epigenetics at Conception

Berkeley, California, United States

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Not SpecifiedCompensation

Senior (5 to 8 years)Experience Level

Full TimeJob Type

UnknownVisa

Biotechnology, Reproductive BiologyIndustries

Requirements

PhD in epigenetics, developmental biology, genetics, stem cell biology or related field, plus related postdoctoral work or industry experience
Strong publication record on the epigenetics of pluripotency or early development
Hands-on human ES/iPSC culture experience (bonus if experience deriving your own iPSC or ES cell lines)
Deep expertise in histone modification and/or DNA methylation profiling and interpretation
Strong fluency with TF-centric chromatin biology and ATAC-seq
Demonstrated experience designing and interpreting datasets such as ChIP-seq, CUT&RUN, ATAC-seq
Familiarity with how to interpret single cell and multi-omic assays (plus)
Working knowledge of X-chromosome dynamics and genomic imprinting in pluripotent and germline contexts
Ability to collaborate deeply with computational biologists to make new discoveries

Responsibilities

Define the key questions and roadmap, framing key questions linking epigenetic signature (X-chromosome dynamics, imprinting erasure/re-establishment, histone modifications, DNA methylation) to germline competence and meiotic progression
Translate and execute experiments to address these questions
Define an epigenetic scorecard: benchmark cells against in vivo counterparts (where available) and identify discrepancies
Make new pluripotent cell lines: derive and benchmark new ‘flavors’ of pluripotent lines to interrogate the impact of somatic epigenetic memory on germline competence
Cross-species comparisons: collaborate with a dedicated epigenetics computational biology scientist to compare human, mouse, and NHP epigenetic profiles vs. germline outcomes
Engineering: when relevant, drive experiments in collaboration with the cell engineering team to explore epigenetic perturbations to potentially mitigate identified epigenetic failure modes
Design and interpret assays of epigenetic state in collaboration with the NGS/sequencing and computational biology team
Independently drive exploration of histone modifications and DNA methylation profiles of cells against in vivo references, and explore how epigenetic status impacts germline competence between species to improve stem cell-derived germ cells

Skills

Key technologies and capabilities for this role

EpigeneticsHistone ModificationsDNA MethylationiPSCsGermline SpecificationMeiosisX-chromosome DynamicsImprintingPluripotent Cell LinesCross-species ComparisonsCell EngineeringEpigenetic Assays

Questions & Answers

Common questions about this position

Is this position remote?

Yes, the position is fully remote.

What experience is required for this Senior Scientist role?

A PhD in epigenetics, developmental biology, genetics, stem cell biology or related field is required, plus related postdoctoral work or industry experience. Candidates need hands-on human ES/iPSC culture experience and deep expertise in histone modification and/or DNA methylation profiling.

What salary or compensation does this role offer?

This information is not specified in the job description.

What is the company culture like at Conception?

Conception is building a world-class team to pioneer reproductive biology, emphasizing high impact work on critical research areas like germline specification.

What makes a strong candidate for this position?

Strong candidates will have a strong publication record on the epigenetics of pluripotency or early development, demonstrated experience designing and interpreting ChIP-seq, CUT&RUN, ATAC-seq datasets, and the ability to collaborate deeply with computational biologists.

Conception

Biotech firm developing egg cells from blood

About Conception

Conception.bio focuses on improving fertility treatments through advanced biotechnology. The company has developed a method to create viable egg cells from blood samples by transforming induced pluripotent stem cells (iPSCs) into mature egg cells. This process allows women to extend their fertility, provides new options for couples facing infertility, and enables genetic screening of embryos to avoid hereditary diseases. Unlike other fertility treatment providers, Conception.bio directly serves individuals and couples, including same-sex male couples, with a unique approach to egg cell development. The goal is to lead the fertility treatment market by offering effective solutions that address the diverse needs of those seeking to conceive.

Berkeley, CaliforniaHeadquarters

2017Year Founded

$23MTotal Funding

SERIES_ACompany Stage

Biotechnology, HealthcareIndustries

51-200Employees

Benefits

Health Insurance

Company Equity

Flexible Work Hours

Risks

Ethical concerns about iPSCs may lead to public backlash and regulatory challenges.

Competition from companies like Dioseve could impact Conception's market share.

Legal challenges in iPSC and fertility treatment IP rights could arise.

Differentiation

Conception turns skin cells into viable human eggs, a groundbreaking fertility innovation.

Their technology offers fertility solutions for women, infertile couples, and same-sex male couples.

Conception's iPSC-based approach allows for genetic screening and potential disease prevention.

Upsides

Growing interest in genetic screening boosts demand for Conception's reproductive technologies.

Advancements in CRISPR enhance Conception's potential for genetic disease prevention.

Fertility treatment market growth presents significant opportunities for Conception's solutions.

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