Senior Quality Control Associate at Lyell Immunopharma

Bothell, Washington, United States

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Not SpecifiedCompensation

Senior (5 to 8 years)Experience Level

Full TimeJob Type

UnknownVisa

Biotechnology, Pharmaceuticals, ImmunotherapyIndustries

Requirements

BS with a minimum of 7 years’ experience in a relevant field (e.g., Cell Biology, Immunology or Flow Cytometry)
MS with a minimum of 4 years’ experience in a relevant field (e.g., Cell Biology, Immunology or Flow Cytometry)
5+ years of experience working in a GMP-regulated laboratory environment
Experience with cell and flow cytometry-based assays is required
Familiarity with software tools for flow cytometry data analysis (e.g., FCS Express)
Strong attention to detail, organizational skills, and ability to work independently on a fixed schedule (Sunday–Wednesday)
3-5 years of experience in a GMP-regulated pharmaceutical, biotech, or related industry
Prior experience in cell therapy environments is a plus
Hands-on experience in a GMP-regulated facility
Proficient in conducting cell-based and flow cytometry-based assays
Experience with Master Control is a plus
Experience with BMRAM is a plus

Responsibilities

Perform cell-based functional assays to assess potency, viability and cytotoxicity for release and stability testing
Execute flow cytometry in-process, release and stability testing
Perform data analysis and data review and approval for release and stability testing
Support and execute method transfer, qualification and validation activities
Participate in authoring test methods and developing and validating blueprints for testing in LIMS
Maintain compliance with GMP regulations and internal SOPs and methods during all QC operations
Initiate, lead and participate in deviations, Change Controls and CAPAs
Collaborate closely with cross-functional teams including QA, Process and Analytical Development, MSAT and Supply Chain
Perform preventative maintenance of QC equipment and ensure the laboratories are consistently clean and organized
Perform QC support duties as assigned

Skills

Key technologies and capabilities for this role

GMPFlow CytometryCell-based AssaysQuality ControlCell TherapyCAR T-cell

Questions & Answers

Common questions about this position

Is this role remote or onsite?

This is an onsite role with no remote work option at the Lyell Manufacturing Facility, LyFE in Bothell, WA.

What are the required skills for this Senior Quality Control Associate position?

The role requires hands-on experience in a GMP-regulated facility, proficiency in conducting cell-based and flow cytometry-based assays, and experience in cell therapy is highly desirable.

What is the work schedule for this position?

The role requires working a Sunday through Wednesday shift, 10 hours per day.

What is the company culture like at Lyell Immunopharma?

Lyell’s culture is based on Science, Respect, Collaboration, and Courage, reflecting the team, environment, and mission's urgency.

What makes a strong candidate for this role?

A highly motivated and detail-oriented candidate with hands-on GMP experience, proficiency in cell-based and flow cytometry assays, and cell therapy background will stand out.

Lyell Immunopharma

Develops advanced cell therapies for cancer

About Lyell Immunopharma

Lyell Immunopharma develops advanced cell therapies aimed at treating solid tumors, which are cancerous tissue masses. The company focuses on enhancing T cells, a type of immune cell, to effectively target and eliminate cancer cells. Their approach includes genetic and epigenetic reprogramming of T cells to address challenges like T cell exhaustion and to ensure T cells can persist in the body. Unlike many competitors, Lyell is dedicated to creating curative treatments specifically for solid tumors, utilizing a diverse product pipeline that explores various treatment methods. The goal is to push the limits of current cancer therapies and provide effective solutions where traditional treatments have not succeeded.

San Francisco, CaliforniaHeadquarters

2018Year Founded

$479.6MTotal Funding

IPOCompany Stage

Biotechnology, HealthcareIndustries

201-500Employees

Benefits

Health Insurance

Dental Insurance

Vision Insurance

Life Insurance

Disability Insurance

Health Savings Account/Flexible Spending Account

Unlimited Paid Time Off

Paid Vacation

Paid Sick Leave

Paid Holidays

401(k) Retirement Plan

401(k) Company Match

Commuter Benefits

Phone/Internet Stipend

Risks

Increased competition in T-cell therapies may impact Lyell's market share.

Delays in clinical data results could lead to investor uncertainty.

Integration challenges from ImmPACT Bio acquisition may divert focus from core operations.

Differentiation

Lyell focuses on T cell reprogramming to treat solid tumors effectively.

Their proprietary Gen-R and Epi-R platforms address T cell exhaustion and stemness.

Lyell's diverse product pipeline explores multiple treatment modalities for solid tumors.

Upsides

Acquisition of ImmPACT Bio enhances Lyell's CAR T-cell therapy capabilities.

Strategic partnership with MaxCyte boosts cell engineering and therapeutic development.

New leadership appointments strengthen Lyell's strategic direction and management.

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