Senior Engineer, Flow Cell Process Development at Element Biosciences

San Diego, California, United States

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Not SpecifiedCompensation

Senior (5 to 8 years)Experience Level

Full TimeJob Type

UnknownVisa

BiotechnologyIndustries

Requirements

Bachelor’s degree in chemical engineering, chemistry, biochemistry, molecular biology, bioengineering, engineering physics, etc. with 3+ years in similar fields
Experience in an Operations/MFG setting, preferably with experience developing and introducing new products, in a fast-paced mid to high volume DNA consumables, Semiconductor, or Surface Chemistry
Creative and independent thinker; excellent communication skills; good team worker; ability to multitask and work independently; and ability to find creative solutions to problems
Experience with implementing and sustaining complex manufacturing equipment and processes, such as automation
Experience in pilot/production environments, including tech transfer activities, sustaining support, or continuous improvement
Ability to resolve complex problems, tasks, and decisions with a team; demonstrated application of structured problem solving such as 8D, A3, DMAIC
Experimental design and statistical data analysis and visualization (such as JMP or R)

Responsibilities

Provide daily hands-on technical support to MFG to meet shared KPI goals—including safety, production outs, equipment utilization, product yield and quality
Provide occasional evening and weekend support to meet production targets (most often remote assistance)
Lead cross-functional investigations and data-driven problem solving, using scientific rigor and structured methodologies to identify root causes and implement corrective actions
Design and execute experiments (DOE, process characterization, and stability studies) to improve process capability, product performance, and manufacturing yield
Lead the development, optimization, and transfer of flow cell manufacturing processes, including surface functionalization, deposition, metrology, and assembly
Working cross-functionally and within NPI teams, translate complex surface chemistry and fluidic design concepts into stable, reproducible production methods
Collaborate with supplier partners to develop and qualify critical components, ensuring alignment with technical specifications and process control standards
Define in-process quality control strategies, inspection plans, and acceptance criteria for flow cell components and assemblies
Develop and maintain technical documentation including user and system requirements, process development reports, and manufacturing instructions
Participate in design reviews, risk assessments, and validation activities to ensure full compliance with quality and regulatory requirements

Skills

DOE

Process Characterization

Stability Studies

Flow Cell Development

Synthetic Chemistry

Organic Chemistry

Nucleotide Chemistry

Enzyme Chemistry

Surface Chemistry

Root Cause Analysis

Data-Driven Problem Solving

Manufacturing Support

Equipment Utilization

Element Biosciences

Next-generation sequencing technology provider

About Element Biosciences

Element Biosciences focuses on next-generation sequencing (NGS) technology, offering the AVITI System, a compact benchtop device that provides high-quality sequencing at a low cost of $1 per million reads. This system is designed for various clients, including academic researchers and pharmaceutical companies, and delivers industry-leading accuracy. Element Biosciences stands out by partnering with other biotech firms, like QIAGEN, to provide complete NGS workflows and by offering the 2023 AVITI for All Grant, which gives free sequencing for diverse applications. The company's goal is to make high-quality sequencing accessible and affordable to accelerate advancements in biotechnology.

San Diego, CaliforniaHeadquarters

2017Year Founded

$659.5MTotal Funding

SERIES_DCompany Stage

Biotechnology, HealthcareIndustries

201-500Employees

Benefits

100% company-paid medical, dental, & vision coverage

Flexible spending & health savings accounts

Premier mental health care

401(k) with immediately vested 4% company match

Company-paid Life and AD&D insurance

Stock option grants

Flexible time off

10 paid annual holidays

8-weeks paid parental leave

Risks

Increased competition from companies like Illumina may impact market share.

Rapid technological advancements require continuous innovation, straining resources.

High cost of AVITI24 may limit adoption among smaller research institutions.

Differentiation

Element Biosciences offers the AVITI System, a low-cost, high-quality sequencing platform.

The company's proprietary technology improves signal-to-noise ratio, enhancing sequencing data quality.

Strategic partnerships with firms like QIAGEN provide comprehensive NGS workflows for clients.

Upsides

AVITI24 platform integrates sequencing and multiomic analysis, revolutionizing cancer research.

Record growth in AVITI System installations indicates strong market demand and acceptance.

Recent executive appointments highlight commitment to leveraging AI for product optimization.

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