Staff Scientist (NGS Applications) at Twist Bioscience

South San Francisco, California, United States

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Not SpecifiedCompensation

Mid-level (3 to 4 years), Senior (5 to 8 years)Experience Level

Full TimeJob Type

UnknownVisa

BiotechnologyIndustries

Requirements

Ph.D. in Molecular Biology, Genomics, Biochemistry, or a combination of closely-related field and experience
Minimum of 2 years of hands-on experience in Next-Generation Sequencing (NGS) applications, specifically with extensive experience in designing, executing, and troubleshooting diverse library preparation workflows
Strong background in general Molecular Biology techniques including mechanical or enzymatic library preparations, NGS library analysis (e.g., Agilent BioAnalyzer and/or TapeStation assays), DNA purification (e.g., SPRI purification), DNA quantification (e.g., Qubit assays), and PCR/qPCR
Direct lab experience and background with Next Generation Sequencing Technology Platforms (e.g., Illumina, PacBio, Ion Torrent, Nanopore etc.), including corresponding sample preparation techniques, preparation and management of outputs from sequencing runs, and day-to-day operation and troubleshooting of physical equipment
Direct lab experience with NGS Target Enrichment Workflows
Demonstrated ability to analyze NGS data output, interpret results, and utilize bioinformatics tools for data visualization and presentation (e.g., R, Python, Jupyter notebooks, matplotlib, ggplot2)
Solid publication record (peer-reviewed articles, patents, or significant contributions to technical reports) and experience writing technical documentation, white papers, or application notes for scientific products
Strong analytical skills

Responsibilities

Provide Molecular Biology Expertise: Apply advanced molecular biology techniques to develop, optimize, and troubleshoot complex NGS workflows, with a focus on maximizing data quality and experimental efficiency
Lead NGS Tools Evaluation & Optimization: Design and execute rigorous experimental plans to test and optimize various NGS library preparation kits and sequencing platforms (e.g., Illumina, PacBio, Oxford Nanopore) with our existing and prospective product lines, ensuring optimal performance and competitive positioning
Customer-Centric Support & Collateral Generation: Contribute to essential post-launch product support with experiments analyzing customer samples, troubleshooting issues, and author high-impact collateral (white papers, technical notes, application briefs) that provide guidance for our users
Product Development Input: Actively participate in the design, development, and validation of novel NGS library preparation kits and applications, offering critical experimental data and technical recommendations
Data Analysis & Visualization: Perform initial assessment of NGS data (e.g., QC metrics, alignment, variant calling outcomes), employing computational tools to visualize and present complex data in a clear and concise manner
Rigorously document experimental procedures, results, and conclusions, ensuring data integrity and reproducibility across all projects
New Technology Implementation: Evaluate and integrate emerging NGS technologies and methodologies to continuously enhance our capabilities and keep our product offerings at the forefront of genomic research

Skills

Key technologies and capabilities for this role

NGSMolecular BiologyIlluminaPacBioOxford NanoporeLibrary PreparationData AnalysisWorkflow Optimization

Questions & Answers

Common questions about this position

What is the salary range for this Scientist position?

Job title and compensation will be determined based on several factors, including but not limited to candidate's years of experience, individual skills, knowledge, and abilities.

Is this NGS Scientist role remote or onsite?

This information is not specified in the job description.

What skills are required for the Scientist position?

Candidates need a Ph.D. in Molecular Biology, Genomics, Biochemistry, or a related field, plus at least 2 years of hands-on NGS experience including library preparation workflows, and strong molecular biology techniques.

What is the work environment like at Twist Bioscience for this role?

The role is on a dynamic Next-Generation Sequencing (NGS) product development team where you will evaluate, optimize, and support cutting-edge NGS solutions.

What makes a strong candidate for the Staff Scientist role?

A highly motivated candidate with a Ph.D., deep expertise in molecular biology and NGS workflows, experience with library preparation kits and sequencing platforms like Illumina, PacBio, and Oxford Nanopore, and skills in data analysis and technical communication stands out.

Twist Bioscience

Produces synthetic DNA for biotechnology applications

About Twist Bioscience

Twist Bioscience specializes in creating synthetic DNA for applications in biotechnology, pharmaceuticals, and research. Their proprietary platform allows for the quick and accurate production of DNA sequences, providing clients with products like genes, oligo pools, and variant libraries. The company stands out by offering high-quality DNA at competitive prices, making them a valuable partner for academic institutions and pharmaceutical companies. Twist Bioscience aims to support advancements in personalized medicine and biotechnology through their innovative DNA synthesis solutions.

South San Francisco, CaliforniaHeadquarters

2013Year Founded

$236.5MTotal Funding

IPOCompany Stage

Biotechnology, HealthcareIndustries

1,001-5,000Employees

Benefits

Health Insurance

Dental Insurance

Vision Insurance

Disability Insurance

Life Insurance

401(k) Retirement Plan

Risks

Increased competition from Ginkgo Bioworks may impact Twist's market share.

Dependency on AI technologies could pose integration and operational challenges.

New CIO appointment may lead to transitional challenges in IT strategy and operations.

Differentiation

Twist Bioscience uses a unique silicon-based DNA synthesis platform for precision and scale.

They offer high-quality DNA sequences at competitive prices, attracting diverse clients.

Their proprietary platform provides instant feedback on DNA sequence synthesis feasibility.

Upsides

Growing demand for synthetic DNA in personalized medicine boosts Twist's market potential.

Collaboration with Absci leverages AI to accelerate antibody discovery and drug development.

Synthetic biology market projected to grow at 28.8% CAGR, benefiting Twist's growth.

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