Scientist/Sr Scientist - Oligonucleotide Chemistry at Eli Lilly and Company

Indianapolis, Indiana, United States

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Not SpecifiedCompensation

Mid-level (3 to 4 years), Senior (5 to 8 years)Experience Level

Full TimeJob Type

UnknownVisa

Pharmaceuticals, Biotechnology, HealthcareIndustries

Requirements

Master's degree in Chemistry, Biochemistry or a relevant scientific field with 5+ years of experience

Responsibilities

Lead the Lilly Genetic Medicines discovery oligosynthesis scale-up team to accelerate Lilly RNAi Therapeutics from pre-clinical to clinical development
Utilize comprehensive expertise in oligonucleotide synthesis methodologies to support Lilly Genetic Medicines and further develop internal capabilities and team growth through effective coaching, mentorship, and leadership
Collaborate with members of the RNAi discovery chemistry teams to validate and execute requirements for oligonucleotide synthesis from 150umol to 6mmol scales including communication of relevant information and results to project leads and/or cross-functional organizations within Lilly to ensure seamless operation of the scale-up team
Actively support efforts toward the discovery of lead drug candidates and lead at the interface with CMC and Development teams to provide essential materials for key studies and effectively communicate technical insights to the development team
Demonstrate expertise in modern synthetic organic and nucleic acid chemistry, striving to improve methods, develop new technologies, and address synthetic oligonucleotide challenges across a diverse portfolio
Oversee and prioritize the work of scale-up team members to meet critical timelines
Value diverse perspectives and experiences for effective solutions. Motivate team members to take initiative, own outcomes, and share expertise on complex technical challenges
Guide teams through unclear situations, adapt efficiently to changes, and evaluate and implement effective approaches to completing tasks

Skills

Oligonucleotide Chemistry

RNA Therapeutics

Genetic Medicines

Medicinal Chemistry

Nucleic Acid Synthesis

Bioconjugation

Analytical Chemistry

HPLC

Mass Spectrometry

Drug Discovery

Eli Lilly and Company

Develops and delivers prescription medicines globally

About Eli Lilly and Company

Eli Lilly and Company is a global pharmaceutical company that focuses on discovering, developing, and delivering medicines to improve health. The company has a long history of scientific achievements, including the creation of insulin, the first life-saving treatment for diabetes. Lilly's operations involve extensive research and development to create new medications and enhance existing ones, ensuring they are safe and effective. Their products are primarily prescription medicines sold to healthcare providers for various medical conditions, including diabetes, cancer, and pain management. What sets Lilly apart from its competitors is its strong commitment to ethical practices and the protection of its products from counterfeiting. The company's goal is to enhance lives through innovative medical solutions while maintaining high standards of quality and ethics.

Indianapolis, IndianaHeadquarters

1876Year Founded

$1,180.1MTotal Funding

IPOCompany Stage

Biotechnology, HealthcareIndustries

10,001+Employees

Risks

Competition from Novo Nordisk's Ozempic may impact tirzepatide's market share.

Potential construction delays in Indiana could affect GLP-1 drug production timelines.

Regulatory challenges may hinder Kisunla's expansion in new Alzheimer's markets.

Differentiation

Eli Lilly's rich history includes the first life-saving insulin treatment.

Lilly's strategic partnerships enhance its position in neurodegenerative disease treatments.

FDA approval of Zepbound opens new therapeutic markets for sleep disorder treatments.

Upsides

Lilly's $9 billion complex in Indiana boosts GLP-1 drug production capacity.

Kisunla's approval in China expands Lilly's Alzheimer's treatment market in Asia.

Collaboration with EVA Pharma enhances Lilly's reputation as socially responsible.

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