Genesis Therapeutics

Principal Software Engineer - Computational Chemistry / Molecular Dynamics

New York, New York, United States

Not SpecifiedCompensation
Junior (1 to 2 years)Experience Level
Full TimeJob Type
UnknownVisa
Biotechnology, Pharmaceuticals, Artificial IntelligenceIndustries

Position Overview

  • Location Type: Remote
  • Employment Type: Full-time
  • Salary: Not specified

Genesis Therapeutics is building a world-class software team to solve problems in drug discovery through machine learning, biophysical simulation, and computational chemistry. We are seeking a Principal Engineer with a deep background in computational chemistry, who is excited to help develop new medicines and play a critical role in building out our software platform.

Requirements

  • Deep background in computational chemistry
  • Experience working in the fields of computational chemistry and drug discovery
  • Experience writing production code and driving projects to completion
  • Comfortable working across all levels of the software stack, building intuitive APIs and libraries for computational chemists
  • Experience working with complex computational chemistry workflows
  • Ability to provide technical and scientific insights to the head of engineering and head of computational chemistry on software architecture.
  • Experience working with data infrastructure to handle large datasets and parallel jobs.
  • Ability to lead, mentor, and coach engineers from both chemistry and computer science backgrounds.

Responsibilities

  • Build and maintain complex computational chemistry workflows for drug discovery.
  • Provide technical and scientific insights to the head of engineering and head of computational chemistry on software architecture.
  • Work closely with computational chemists and CADD scientists to productionize new computational methods for molecular property prediction.
  • Help scale the data infrastructure to handle billions of datapoints and hundreds of thousands of parallel QM and molecular dynamics jobs.
  • Lead, mentor, and coach engineers - both from chemistry and computer science backgrounds.

Company Information

Genesis Therapeutics is unifying AI and biotech to discover novel and breakthrough treatments for patients with severe and devastating conditions. Genesis was founded on groundbreaking molecular ML research and since has established itself as the industry leader in AI for small molecule drug discovery. Our team of accomplished biotech leaders and expert drug hunters joins forces with deep learning researchers and software engineers who are pioneering predictive and generative AI technologies for molecules.

Our team has created the industry's most advanced molecular AI platform called GEMS (Genesis Exploration of Molecular Space), to accelerate and optimize small molecule drug discovery and to enable the discovery of novel first-in-class and best-in-class small molecule drugs for challenging and/or undruggable targets. The company has leveraged GEMS to build an internal pipeline with multiple programs against high-value targets, including data-poor and canonically undruggable targets where GEMS is uniquely advantaged.

What We Offer

  • The opportunity to work on high-impact tools and products that are immediately deployed to accelerate the discovery of new medicines.
  • Strong technical coworkers in AI, software, and chemistry, who all have a powerful mix of intellectual curiosity and humility. The team reads and discusses 1-2 machine learning or chemistry papers every week to stay on top of the field and inspire new ideas.
  • Competitive salary and equity.
  • Medical, dental, and vision insurance, and a 401(k) program.

Skills

Computational Chemistry
Drug Discovery
Machine Learning
Biophysical Simulation
Software Development
API Development
Workflow Automation
Data Infrastructure
Parallel Computing
Mentoring
Project Leadership

Genesis Therapeutics

AI-driven drug discovery for pharmaceuticals

About Genesis Therapeutics

Genesis Therapeutics accelerates the development of new medicines by using artificial intelligence in drug discovery. The company combines 3D spatial graph modeling and molecular simulation to identify potential drug candidates and explore new chemical spaces. Unlike its competitors, Genesis Therapeutics focuses on strategic partnerships with other biotech and pharmaceutical companies, generating revenue through upfront payments and future earnings based on drug success. The goal is to transform the drug discovery process and bring new therapies to market.

Burlingame, CaliforniaHeadquarters
2019Year Founded
$272.5MTotal Funding
SERIES_BCompany Stage
AI & Machine Learning, BiotechnologyIndustries
51-200Employees

Benefits

Competitive salary
Equity
Medical, dental, & vision insurance
401(k) program

Risks

Competition from AI-driven companies like Insilico Medicine and Exscientia is increasing.
Over-reliance on partnerships could lead to financial instability if drugs aren't successful.
Rapid AI advancements may render current models like GEMS obsolete without updates.

Differentiation

Genesis Therapeutics uses AI to accelerate drug discovery with 3D spatial graph modeling.
The GEMS platform integrates deep learning, molecular simulations, and generative AI for drug design.
Strategic partnerships with Eli Lilly and Gilead highlight Genesis' industry collaboration strength.

Upsides

Partnership with NVIDIA enhances GEMS platform for targeting undruggable diseases.
$224 million equity investment boosts research and development capabilities.
Recognition as a 'Fierce 15' company underscores AI's role in breakthrough therapeutics.

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