Scientist/Sr Scientist - Oligonucleotide Analytics at Eli Lilly and Company

Indianapolis, Indiana, United States

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Not SpecifiedCompensation

Mid-level (3 to 4 years), Senior (5 to 8 years)Experience Level

Full TimeJob Type

UnknownVisa

Pharmaceuticals, BiotechnologyIndustries

Requirements

Extensive hands-on experience in the analytical characterization and development of oligonucleotides and their conjugates, primarily using LCMS instruments
Proven track record with liquid chromatography, mass spectrometry, and other advanced analytical techniques
Experience with large-scale sample preparation and applying automation to sample preparation or formulation (strong plus)
Strong technical problem-solving skills and ability to quickly learn and apply new technologies or explore new fields
Ability to work independently while delivering high-quality, efficient results in a fast-paced environment
M.S. in Chemistry, Analytical Chemistry, Biophysics, Biochemistry

Responsibilities

Perform sample preparation for forced degradation and solution stability studies to support developability evaluation at the candidate selection stage for oligonucleotides and their conjugates, including carbohydrates, lipids, small molecules, and others
Characterize the solubility, and physical and chemical stability of drug candidates and formulations using various analytical techniques, including but not limited to chromatography, mass spectrometry, microscopy, thermal analysis, dynamic light scattering, pharmaceutical particle counting, and backgrounded membrane imaging
Design and develop LC/LCMS-based methods to elucidate impurities and degradants from API and stability samples
Partner with the Early Phase TIDES team and the drug discovery team to identify appropriate analytical data packages to support method and project transfers as needed
Identify and mitigate technical risks affecting the performance and production of drug candidates
Demonstrate exceptional teamwork and learning agility to solve complex technical problems and to identify and implement novel formulations based on drug delivery technologies that enhance patient benefit and add value to Lilly
Collaborate with, inspire, and influence the external scientific community to drive innovation, foster collaborations, and strengthen Lilly's internal portfolio
Continuously refine and improve existing analytical methods and assays, and innovate as necessary to meet evolving program needs
Rapidly assimilate new technologies and apply cross-disciplinary scientific concepts to address complex analytical challenges
Maintain thorough, accurate, and timely documentation of experiments, protocols, and results in electronic laboratory notebooks and technical reports
Ensure high standards of laboratory practice, including compliance with safety and quality guidelines, and promote operational excellence in all analytical activities
Communicate findings and progress effectively, including regular presentations in project team, department, and governance meetings

Skills

LCMS

Liquid Chromatography

Mass Spectrometry

Oligonucleotide Analytics

Sample Preparation

Forced Degradation Studies

Solution Stability Studies

Automation

Analytical Characterization

Eli Lilly and Company

Develops and delivers prescription medicines globally

About Eli Lilly and Company

Eli Lilly and Company is a global pharmaceutical company that focuses on discovering, developing, and delivering medicines to improve health. The company has a long history of scientific achievements, including the creation of insulin, the first life-saving treatment for diabetes. Lilly's operations involve extensive research and development to create new medications and enhance existing ones, ensuring they are safe and effective. Their products are primarily prescription medicines sold to healthcare providers for various medical conditions, including diabetes, cancer, and pain management. What sets Lilly apart from its competitors is its strong commitment to ethical practices and the protection of its products from counterfeiting. The company's goal is to enhance lives through innovative medical solutions while maintaining high standards of quality and ethics.

Indianapolis, IndianaHeadquarters

1876Year Founded

$1,180.1MTotal Funding

IPOCompany Stage

Biotechnology, HealthcareIndustries

10,001+Employees

Risks

Competition from Novo Nordisk's Ozempic may impact tirzepatide's market share.

Potential construction delays in Indiana could affect GLP-1 drug production timelines.

Regulatory challenges may hinder Kisunla's expansion in new Alzheimer's markets.

Differentiation

Eli Lilly's rich history includes the first life-saving insulin treatment.

Lilly's strategic partnerships enhance its position in neurodegenerative disease treatments.

FDA approval of Zepbound opens new therapeutic markets for sleep disorder treatments.

Upsides

Lilly's $9 billion complex in Indiana boosts GLP-1 drug production capacity.

Kisunla's approval in China expands Lilly's Alzheimer's treatment market in Asia.

Collaboration with EVA Pharma enhances Lilly's reputation as socially responsible.

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