Scientist– Oligonucleotide Chemistry at Eli Lilly and Company

Boston, Massachusetts, United States

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Not SpecifiedCompensation

Senior (5 to 8 years)Experience Level

Full TimeJob Type

UnknownVisa

Pharmaceuticals, Biotechnology, HealthcareIndustries

Requirements

Bachelor's or Master's Degree in chemistry, biochemistry, pharmacology, or related scientific field
1+ years of work experience in an academic laboratory, or preferably in an industrial setting
Demonstrated expertise in organic synthesis and advanced chromatographic purification techniques
Proven laboratory proficiency with analytical instruments such as HPLC and LC-MS
Strong research track record in synthetic organic chemistry/chemical biology/biotechnology
Analytically minded, systematic, and embrace data-driven decision making

Responsibilities

Design and execution of automated workflows for synthesizing, purifying, and analyzing ASOs, siRNAs, SSOs, and related oligonucleotides across various chemistries and scales using advanced instrumentation platforms
Perform synthesis and chromatographic purification of innovative phosphoramidite monomers, and carry out conjugation of novel ligands—such as small molecules and peptides—to oligonucleotides for targeted delivery
Apply analytical techniques including UV-Vis spectroscopy, NMR, HPLC, and LC-MS to evaluate both crude and purified synthetic compounds
Interpret and organize analytical data and research outcomes for presentation to project teams
Support resolution of technical issues and contribute scientific and technical insights to ongoing projects
Provide strategic input into experimental planning, integrated data analysis, and effective communication of results to scientific teams and leadership
Maintain meticulous records of experimental procedures and key steps to ensure reproducibility, including accurate documentation in electronic lab notebooks in accordance with Lilly’s quality standards
Assist with general lab operations such as ordering supplies, preparing reagents, and maintaining equipment
Collaborate closely with colleagues across multiple sub-teams within the Lilly LGM group
Adhere strictly to all health and safety protocols
Demonstrate a strong commitment to fostering a diverse and inclusive laboratory environment every day

Skills

Key technologies and capabilities for this role

Synthetic Organic ChemistryOligonucleotide ChemistryChemical BiologyBiotechnologyRNA TherapeuticsRNA Synthesis

Questions & Answers

Common questions about this position

What is the work location for this Scientist position?

The position is based at the Lilly Innovation Center in Boston, Massachusetts.

What salary or compensation does this role offer?

This information is not specified in the job description.

What key skills are required for the Scientist– Oligonucleotide Chemistry role?

The role requires a strong research track record in synthetic organic chemistry/chemical biology/biotechnology, proficiency in oligonucleotide synthesis (ASOs, siRNAs, SSOs), chromatographic purification, conjugation of ligands, and analytical techniques like UV-Vis, NMR, HPLC, and LC-MS.

What is the company culture like at Eli Lilly's Boston Innovation Center?

The Genetic Medicine team shares a passion for challenging conventional wisdom, embraces creative break-through concepts, and offers a start-up environment with large company support in the heart of Massachusetts’ science and technology cluster.

What makes a strong candidate for this oligonucleotide chemistry scientist role?

Strong candidates will be analytically minded, systematic, embrace data-driven decision making, have a strong research track record in synthetic organic chemistry or related fields, and demonstrate the ability to collaborate with multidisciplinary teams.

Eli Lilly and Company

Develops and delivers prescription medicines globally

About Eli Lilly and Company

Eli Lilly and Company is a global pharmaceutical company that focuses on discovering, developing, and delivering medicines to improve health. The company has a long history of scientific achievements, including the creation of insulin, the first life-saving treatment for diabetes. Lilly's operations involve extensive research and development to create new medications and enhance existing ones, ensuring they are safe and effective. Their products are primarily prescription medicines sold to healthcare providers for various medical conditions, including diabetes, cancer, and pain management. What sets Lilly apart from its competitors is its strong commitment to ethical practices and the protection of its products from counterfeiting. The company's goal is to enhance lives through innovative medical solutions while maintaining high standards of quality and ethics.

Indianapolis, IndianaHeadquarters

1876Year Founded

$1,180.1MTotal Funding

IPOCompany Stage

Biotechnology, HealthcareIndustries

10,001+Employees

Risks

Competition from Novo Nordisk's Ozempic may impact tirzepatide's market share.

Potential construction delays in Indiana could affect GLP-1 drug production timelines.

Regulatory challenges may hinder Kisunla's expansion in new Alzheimer's markets.

Differentiation

Eli Lilly's rich history includes the first life-saving insulin treatment.

Lilly's strategic partnerships enhance its position in neurodegenerative disease treatments.

FDA approval of Zepbound opens new therapeutic markets for sleep disorder treatments.

Upsides

Lilly's $9 billion complex in Indiana boosts GLP-1 drug production capacity.

Kisunla's approval in China expands Lilly's Alzheimer's treatment market in Asia.

Collaboration with EVA Pharma enhances Lilly's reputation as socially responsible.

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