Scientist - Mass Spectrometry at Eli Lilly and Company

Boston, Massachusetts, United States

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Not SpecifiedCompensation

Mid-level (3 to 4 years), Senior (5 to 8 years)Experience Level

Full TimeJob Type

UnknownVisa

Pharmaceuticals, BiotechnologyIndustries

Requirements

Bachelor’s or Master’s degree in Analytical Chemistry, Biochemistry, Chemistry, Food Science, or a related scientific field, with over 2 years of relevant post-graduate experience in industry
Extensive hands-on experience in analytical techniques for characterizing and analyzing small molecules, biologics, and/or oligonucleotides
Proven track record in analytical method development and troubleshooting
Experience with liquid chromatography, (high resolution) mass spectrometry, and other advanced analytical techniques
Strong technical problem-solving skills
Computer savvy with the ability to navigate multiple instrument control programs and data analysis environments
Ability to work independently to achieve efficient, quality results in a fast-paced environment
Strong analytical thinking skills with a demonstrated ability to articulate issues and extract and synthesize complex information into key focus areas (Additional Skills/Preferences)
Extensive experience in operating and troubleshooting a range of mass spectrometers including Q-ToF, QQQ and Orbitrap (Additional Skills/Preferences)
Proficient with Thermo XCalibur, Agilent ChemStation and MassHunter software (Additional Skills/Preferences)

Responsibilities

Work closely with the chemistry team to source, explore, and implement the latest separation science and analytical technologies for the purification and characterization of oligonucleotides and their conjugates, including carbohydrates, lipids, peptides, and proteins
Conduct LC and LC-MS based method development for sensitive characterization of biologics including intact mass, reduced mass, peptide mapping, and glycan mapping to provide better understanding of attributes
Conduct semi-preparative and preparative method development activities to advance downstream processing for challenging modified oligonucleotides, utilizing RP purification, ion-exchange chromatography, spin filtration, TFF, FPLC, size exclusion chromatography, and MS-direct auto-scale preparative LC-MS techniques
Work with contractors and third-party vendors to troubleshoot and maintain lab instruments, including but not limited to UPLC, LC-MS, osmometer, and NanoDrop, ensuring they remain in peak operational condition
Learn new technologies quickly and apply effective scientific concepts and methods across multiple areas
Process and present data leveraging Microsoft Office apps, GraphPad and Spotfire for data organization and data visualization
Document experiments, data, technical reports, and findings electronically in an accessible manner with good documentation practices
Present findings, progress, and data proactively and regularly in group and department meetings
Possess a collaborative and willing-to-share mindset with excellent verbal and written communication skills, presentation skills, and attention to detail
Ability to follow Global Health, Safety & Environment Center (HSE) guidelines while performing tasks

Skills

Mass Spectrometry

LC-MS

Liquid Chromatography

Analytical Method Development

High Resolution Mass Spectrometry

Oligonucleotides

Small Molecules

Biologics

Separation Science

Troubleshooting

Data Analysis

Eli Lilly and Company

Develops and delivers prescription medicines globally

About Eli Lilly and Company

Eli Lilly and Company is a global pharmaceutical company that focuses on discovering, developing, and delivering medicines to improve health. The company has a long history of scientific achievements, including the creation of insulin, the first life-saving treatment for diabetes. Lilly's operations involve extensive research and development to create new medications and enhance existing ones, ensuring they are safe and effective. Their products are primarily prescription medicines sold to healthcare providers for various medical conditions, including diabetes, cancer, and pain management. What sets Lilly apart from its competitors is its strong commitment to ethical practices and the protection of its products from counterfeiting. The company's goal is to enhance lives through innovative medical solutions while maintaining high standards of quality and ethics.

Indianapolis, IndianaHeadquarters

1876Year Founded

$1,180.1MTotal Funding

IPOCompany Stage

Biotechnology, HealthcareIndustries

10,001+Employees

Risks

Competition from Novo Nordisk's Ozempic may impact tirzepatide's market share.

Potential construction delays in Indiana could affect GLP-1 drug production timelines.

Regulatory challenges may hinder Kisunla's expansion in new Alzheimer's markets.

Differentiation

Eli Lilly's rich history includes the first life-saving insulin treatment.

Lilly's strategic partnerships enhance its position in neurodegenerative disease treatments.

FDA approval of Zepbound opens new therapeutic markets for sleep disorder treatments.

Upsides

Lilly's $9 billion complex in Indiana boosts GLP-1 drug production capacity.

Kisunla's approval in China expands Lilly's Alzheimer's treatment market in Asia.

Collaboration with EVA Pharma enhances Lilly's reputation as socially responsible.

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