Scientist, Cell Biology at Arcellx

Rockville, Maryland, United States

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Not SpecifiedCompensation

Mid-level (3 to 4 years), Senior (5 to 8 years)Experience Level

Full TimeJob Type

UnknownVisa

BiotechnologyIndustries

Requirements

Master’s degree and 4-6+ years research experience within the pharmaceutical industry or PhD-level scientist from a relevant field and 0-2 years industry experience
Background in Chimeric Antigen Receptor (CAR) T-cells or alternative cell-based cancer therapeutics
Background in T-cell signaling and/or cytokine signaling and cytokine biology
Background in Solid Tumor Immunology (Tumor Infiltrating Lymphocytes, Myeloid Derived Suppressor Cells, Tumor Associated Macrophages, Regulatory T-cells)
Expertise in manipulating immune cells, particularly T cells, including purification, transfection/transduction, activation and expansion
Experience with in vivo models of human cancer, including cell line derived xenografts or patient-derived xenografts
Expertise in complex immune cell assays including multiparameter flow cytometry, in vitro cell based assays (e.g. cytotoxicity, proliferation, degranulation), live cell analysis, and multiplex assays
Familiarity with methods to pre-clinically assess efficacy, specificity, and safety of CAR-T cells or other novel immuno-oncology agents
Commitment to ethical scientific investigations and rigorous experimental methods
Ability and desire to multitask and function in a fast-paced entrepreneurial environment
Interpersonal skills that promote a collaborative and productive lab environment
Stay up to date with relevant technical and intellectual scientific expertise in tumor biology and cancer modelling, particularly as it relates to CAR-T cell biology or other cell-based therapies

Responsibilities

Contribute to one or more pipeline programs, working collaboratively with cross-functional teams to ensure the timely generation and dissemination of critical program data to enable data-driven decisions
Design and execute experiments independently with minimal supervision, as well as effectively plan and organize work activities and prioritize task completion
Serve as a functional area lead within a project setting; helping to derive timelines, plan, and execute to help achieve project goals

Skills

Cell Biology

Cell Therapy

Immunotherapy

Drug Discovery

Assay Development

Cross-functional Collaboration

Pipeline Development

Arcellx

Develops immunotherapies for cell therapy

About Arcellx

Arcellx develops immunotherapies aimed at improving cell therapy for serious diseases. Their products focus on advanced techniques that enhance the effectiveness of treatments. The company collaborates with healthcare providers and research institutions to bring these therapies to patients. Unlike many competitors, Arcellx emphasizes proprietary products and partnerships to drive their research and development efforts. The goal is to meet unmet medical needs by providing safe and effective treatment options through their innovative approach to cell therapy.

Gaithersburg, MarylandHeadquarters

2014Year Founded

$194.5MTotal Funding

IPOCompany Stage

Biotechnology, HealthcareIndustries

51-200Employees

Benefits

Health Insurance

Dental Insurance

Vision Insurance

Unlimited Paid Time Off

Flexible Work Hours

401(k) Company Match

Fully-Paid Parental Leave

Tuition Reimbursement

Relocation Assistance

Risks

Competition from established CAR-T therapies like Abecma and Carvykti could limit market share.

Dependency on Gilead's Kite partnership poses risks if partnership dynamics change.

Phase 3 iMMagine-3 trial delays or failures could impact anito-cel's market timeline.

Differentiation

Arcellx's CART-ddBCMA has FDA Fast Track and Orphan Drug designations.

The novel D-Domain binder in anito-cel enhances antigen binding and cell killing.

ARC-SparX offers dosable and controllable CAR-T therapy options.

Upsides

Growing investment in personalized medicine aligns with Arcellx's tailored immunotherapies.

Advancements in gene editing like CRISPR enhance precision in engineered cell therapies.

Outpatient CAR-T administration could reduce costs and increase accessibility for Arcellx.

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