Post Doctoral Scientist - Large Molecule Discovery at Eli Lilly and Company

San Francisco, California, United States

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Not SpecifiedCompensation

Expert & Leadership (9+ years)Experience Level

Full TimeJob Type

UnknownVisa

Biotechnology, Pharmaceuticals, OncologyIndustries

Requirements

PhD in chemistry, biochemistry, or other related scientific discipline

Responsibilities

Work within a scientific team, conceptualizing and executing new site-specific bioconjugation and linker technologies for diverse modalities such as ADCs, ARCs, DACs etc
Implement state-of-the-art bioconjugation technologies (cysteine, lysine, site-specific and other) and utilize novel chemistries to generate bioconjugates
Develop purification strategies (up to 200 mg) with affinity, ion-exchange, hydrophobic interaction, size exclusion, and tangential flow filtration
Characterize ADCs using UV-Vis, SEC, HIC, RP, IEX, cIEF, and LC-MS
Maintain thorough documentation of experimental procedures in electronic notebook or database, writing of reports and technical documents
Maintain scientific and technical expertise through familiarity with scientific literature and attending conferences
Engage with multidisciplinary project teams to design, execute, and interpret experiments
Present periodic updates and reports to management team
Maintain a safe, pleasant, and efficient working environment

Skills

Key technologies and capabilities for this role

bioconjugationADClinker technologiescysteine conjugationlysine conjugationsite-specific conjugationpurificationaffinity chromatographyion-exchange chromatographyhydrophobic interaction chromatographysize exclusion chromatographytangential flow filtrationUV-VisSECHICRP-HPLCIEXcIEFLC-MS

Questions & Answers

Common questions about this position

What are the basic qualifications for this Postdoctoral Scientist role?

A PhD in chemistry, biochemistry, or other related scientific discipline is required.

What preferred experiences are highlighted for this position?

Strong hands-on experience producing and characterizing antibody and protein drug conjugates using HIC, SEC, LC-MS, IEX, and RP-HPLC, along with experience in protein purification systems like AKTA FPLCs, is preferred.

What kind of teamwork is expected in this role?

The role requires working within a multi-disciplinary scientific team and engaging effectively with small-molecule research project teams, demonstrating high collaboration, interpersonal skills, and ability to work well with professionals across functions.

Is this position remote or office-based?

This information is not specified in the job description.

What salary or compensation does this role offer?

This information is not specified in the job description.

Eli Lilly and Company

Develops and delivers prescription medicines globally

About Eli Lilly and Company

Eli Lilly and Company is a global pharmaceutical company that focuses on discovering, developing, and delivering medicines to improve health. The company has a long history of scientific achievements, including the creation of insulin, the first life-saving treatment for diabetes. Lilly's operations involve extensive research and development to create new medications and enhance existing ones, ensuring they are safe and effective. Their products are primarily prescription medicines sold to healthcare providers for various medical conditions, including diabetes, cancer, and pain management. What sets Lilly apart from its competitors is its strong commitment to ethical practices and the protection of its products from counterfeiting. The company's goal is to enhance lives through innovative medical solutions while maintaining high standards of quality and ethics.

Indianapolis, IndianaHeadquarters

1876Year Founded

$1,180.1MTotal Funding

IPOCompany Stage

Biotechnology, HealthcareIndustries

10,001+Employees

Risks

Competition from Novo Nordisk's Ozempic may impact tirzepatide's market share.

Potential construction delays in Indiana could affect GLP-1 drug production timelines.

Regulatory challenges may hinder Kisunla's expansion in new Alzheimer's markets.

Differentiation

Eli Lilly's rich history includes the first life-saving insulin treatment.

Lilly's strategic partnerships enhance its position in neurodegenerative disease treatments.

FDA approval of Zepbound opens new therapeutic markets for sleep disorder treatments.

Upsides

Lilly's $9 billion complex in Indiana boosts GLP-1 drug production capacity.

Kisunla's approval in China expands Lilly's Alzheimer's treatment market in Asia.

Collaboration with EVA Pharma enhances Lilly's reputation as socially responsible.

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