Director, Clinical Translational Safety Lead at Johnson & Johnson

Spring House, Pennsylvania, United States

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Not SpecifiedCompensation

Senior (5 to 8 years), Expert & Leadership (9+ years)Experience Level

Full TimeJob Type

UnknownVisa

Pharmaceuticals, Healthcare, BiotechnologyIndustries

Requirements

Well-rounded physician scientist (MD preferred, given job sub-function)
Investigative mind and track record of excellent communication and collaboration in cross-functional, complex, fast-paced, highly matrixed environments
Deep understanding of systems and pathway biology, mechanistic pathobiology, and biochemistry
Ability to “translate” pathologic and clinical findings into disease phenotypes
Expertise to guide strategy for mechanistic de-risking and understanding of safety signals in pre-clinical and clinical development across multiple therapeutic areas (oncology, immunology, neurosciences, ophthalmology, others)
Experience working with global teams in toxicology, safety pharmacology, pathobiology, DMPK, and bioanalysis
Creative scientific, translational, and strategic mindset
Ability to identify opportunities for cross-disciplinary project impact, raise scientific standards, and challenge/defend scientific/strategic views to senior management

Responsibilities

Guide strategy for mechanistic de-risking and understanding of safety signals in pre-clinical and clinical development within a multi-modality portfolio
Build strong partnerships with Translational Research, Global Medical Safety, Clinical Pharmacology, investigative toxicology, pathobiology, safety pharmacology, and other pre-clinical sciences
Set investigative pre-clinical strategy and bridge knowledge between pre-clinical and clinical disciplines to advance new medicines into the clinic
Contribute to discovery programs by providing expert interpretation and contextualization of competitive intelligence around clinical safety data in collaboration with medical safety officers, translational leads, and compound development team leaders
Establish a robust translational safety assessment framework
Ensure clinical insights are translated back into discovery to inform and optimize preclinical safety models and improve safety profiles of future therapies
Work as part of the Translational Safety leadership team (individual contributor role reporting to Executive Director, Global Translational Safety)

Skills

Clinical Development

Translational Safety

Preclinical Safety

Safety Pharmacology

Oncology

Immunology

Neuroscience

Ophthalmology

Mechanistic De-risking

Johnson & Johnson

Healthcare products in pharmaceuticals and devices.

About Johnson & Johnson

Johnson & Johnson operates in the healthcare sector with three main areas: pharmaceuticals, medical devices, and consumer health products. In the pharmaceuticals segment, the company develops prescription drugs for various medical conditions such as cancer and infectious diseases. The medical devices segment provides products used in surgeries and other medical procedures, while the consumer health segment offers over-the-counter products, including baby care and personal health items. Johnson & Johnson generates revenue through direct sales and partnerships, and it invests significantly in research and development to create new products that meet the needs of consumers and healthcare providers. The company stands out from competitors by emphasizing diversity, equity, and inclusion in its workplace, fostering an environment where employees can share their perspectives. Its goal is to improve patient outcomes and enhance the overall health and well-being of individuals globally.

New Brunswick, New JerseyHeadquarters

1886Year Founded

IPOCompany Stage

HealthcareIndustries

10,001+Employees

Risks

J&J faces a class action lawsuit in Australia over ineffective cold and flu medications.

Former J&J executives joining other firms could lead to increased competition.

Ongoing legal battles, like the lawsuit against Cigna, pose financial liabilities for J&J.

Differentiation

J&J operates in three segments: pharmaceuticals, medical devices, and consumer health.

The company invests heavily in R&D for innovative medical solutions and products.

J&J is committed to diversity, equity, and inclusion in its workplace culture.

Upsides

J&J's collaboration with Helsinki University Hospital focuses on value-based healthcare models.

The rise of personalized medicine offers J&J opportunities in targeted therapies.

Increased focus on digital health solutions presents expansion opportunities for J&J.

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