Associate Director, Clinical Data Management at Tango Therapeutics

Boston, Massachusetts, United States

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Not SpecifiedCompensation

Senior (5 to 8 years), Expert & Leadership (9+ years)Experience Level

Full TimeJob Type

UnknownVisa

Biotechnology, Precision OncologyIndustries

Requirements

Bachelor’s degree in computer science, or a science-based subject with at least 8 years of clinical data management experience in industry, with experience across indications and EDC platforms like Metadata Rave
5-8 years of experience leading the data management of clinical trials, from study start up through database lock, within an industry sponsor, ideally focusing on oncology or rare diseases
Strong vendor management and oversight experience
Solid technical skills across data platforms; programming experience preferred
Experienced in designing clinical trials utilizing CDASH and SDTM standard terminology
Cross collaboration proficiency with other related functions such as Biostatistics, Statistical Programming, and Pharmacovigilance
Understanding of FDA and ICH GCP guidelines to ensure appropriate reporting of clinical trial data
Experience in regulatory GCP inspections/audits preferred
Experience with Spotfire, elluminate or other data visualization software
Ability to manage multiple projects in a fast-paced environment

Responsibilities

Lead the clinical data management partnership with CROs, ensuring seamless execution of Tango’s clinical trials
Provide oversight for fully outsourced data management activities from RFP to final database lock, working closely with CROs to develop and standardize data handling plans, data transfer specifications, metrics, and data review tools
Develop and/or author key data management documents, including database design specifications, edit checks, CRF completion guidelines, and Data Management Plans, ensuring compliance with CDASH and SDTM standards
Partner with cross-functional teams to standardize data collection and reporting processes, enhancing efficiency and data quality
Guide and monitor data cleaning, discrepancy management, and data reconciliation activities with external vendors and internal stakeholders
Provide leadership and oversight for user acceptance testing (UAT) of eCRFs and associated edit checks
Establish, review and monitor data quality metrics to ensure clean, consistent, and analyzable datasets
Collaborate with internal and external stakeholders (CROs, software vendors, clinical development partners, specialty labs, etc.) to ensure projects are delivered on time and within budget
Participate in study team meetings, providing updates, addressing issues, and ensuring data is effectively collected, reviewed, and analyzed

Skills

Key technologies and capabilities for this role

Clinical Data ManagementCRO OversightData Management PlansDatabase DesignEdit ChecksCRF Completion GuidelinesCDASHSDTMData Transfer SpecificationsData Review ToolsRFP ManagementDatabase Lock

Questions & Answers

Common questions about this position

What is the location for this role at Tango Therapeutics?

The Tango labs and offices are located at 201 Brookline Avenue in the Fenway area of Boston, Massachusetts.

What salary or compensation is offered for the Associate Director position?

This information is not specified in the job description.

What experience and education are required for this clinical data management role?

A Bachelor’s degree in computer science or a science-based subject is required, along with at least 8 years of clinical data management experience in industry across indications and EDC platforms.

What kind of work environment does Tango Therapeutics offer?

This role is ideal for someone who thrives in a dynamic environment, excels at collaboration, and is passionate about ensuring high-quality clinical data.

What makes a strong candidate for the Associate Director, Clinical Data Management position?

Candidates should have a Bachelor’s degree in computer science or a science-based subject with at least 8 years of clinical data management experience across indications and EDC platforms, plus strong leadership in vendor oversight and cross-functional collaboration.

Tango Therapeutics

Develops targeted cancer therapies using synthetic lethality

About Tango Therapeutics

Tango Therapeutics develops targeted cancer treatments using the principle of synthetic lethality, which allows them to design drugs that kill cancer cells while leaving healthy cells unharmed. Their approach focuses on the interaction between genes, where the loss of both genes leads to cell death, but the loss of only one does not. This method enables them to create therapies that are more precise in targeting tumors. Tango operates in the oncology market, primarily serving healthcare providers and pharmaceutical companies interested in advanced cancer therapies. They collaborate with larger pharmaceutical firms, like Gilead Sciences, to co-develop their treatments, which helps in funding and speeding up the process of bringing these drugs to market. Tango's goal is to advance their pipeline of targeted immunotherapies through strong research and development efforts and strategic partnerships.

Cambridge, MassachusettsHeadquarters

2017Year Founded

$341.4MTotal Funding

IPOCompany Stage

Biotechnology, HealthcareIndustries

51-200Employees

Benefits

Hybrid Work Options

Risks

Discontinuation of TNG348 due to liver toxicity may affect investor confidence.

Reliance on partnerships for financial support poses risks if partnerships change.

Intensifying competition in precision oncology could impact Tango's market share.

Differentiation

Tango leverages synthetic lethality to target cancer cells while sparing healthy ones.

Their focus includes counteracting tumor suppressor gene loss and immune evasion.

Strategic collaborations with pharma companies accelerate development and commercialization of therapies.

Upsides

Growing interest in synthetic lethality enhances Tango's innovative approach in oncology.

Recent $80 million financing strengthens Tango's financial position for future developments.

FDA clearance for TNG348 and TNG462 boosts Tango's clinical trial advancements.

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