Advisor – Stem Cell Engineering and Cell Line Development at Eli Lilly and Company

Boston, Massachusetts, United States

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Not SpecifiedCompensation

Senior (5 to 8 years), Expert & Leadership (9+ years)Experience Level

Full TimeJob Type

UnknownVisa

Pharmaceuticals, Biotechnology, HealthcareIndustries

Requirements

PhD level scientist
Extensive experience with human iPSC culture
Extensive experience with gene editing
Extensive experience with molecular biology
Extensive experience with assay development
Experience bridging R&D and GMP gene-editing

Responsibilities

Establish iPSC platform capabilities, including advancing iPSC gene-editing and cell line development toward GMP operation
Develop and optimize workflows for iPSC gene-editing using existing and novel genome editing tools, including guide RNA design, RNP delivery, clone characterization, and banking
Perform clone characterization via assays such as flow cytometry, DNA-based assays, ddPCR, and next-generation sequencing (NGS)
Execute genome editing of iPSC in GMP facilities to create clinical cell lines
Evaluate and design mitigating mechanisms to ensure genomic stability of the iPSC lines
Implement high throughput CRISPR and compound screens
Design and implement safety switch strategies for cell therapy products
Execute routine directed differentiation of iPSC lines towards islet cells and characterize drug product attributes
Collaborate with cross-functional teams to transition from research to GMP-grade reagents and processes and actively participate in bridging R&D and GMP editing
Stay current with advancements in gene editing technologies and apply them to ongoing projects
Ensure all gene editing activities comply with relevant regulatory guidelines and standards
Maintain excellent scientific documentation, prepare reports, present in meetings, and contribute to SOP and batch record development
Contribute to the preparation of regulatory documents, including INDs, BLAs, and other necessary documentation
Demonstrate ability to work effectively with management and influence team members across multiple teams

Skills

iPSC

gene editing

stem cell engineering

cell line development

Eli Lilly and Company

Develops and delivers prescription medicines globally

About Eli Lilly and Company

Eli Lilly and Company is a global pharmaceutical company that focuses on discovering, developing, and delivering medicines to improve health. The company has a long history of scientific achievements, including the creation of insulin, the first life-saving treatment for diabetes. Lilly's operations involve extensive research and development to create new medications and enhance existing ones, ensuring they are safe and effective. Their products are primarily prescription medicines sold to healthcare providers for various medical conditions, including diabetes, cancer, and pain management. What sets Lilly apart from its competitors is its strong commitment to ethical practices and the protection of its products from counterfeiting. The company's goal is to enhance lives through innovative medical solutions while maintaining high standards of quality and ethics.

Indianapolis, IndianaHeadquarters

1876Year Founded

$1,180.1MTotal Funding

IPOCompany Stage

Biotechnology, HealthcareIndustries

10,001+Employees

Risks

Competition from Novo Nordisk's Ozempic may impact tirzepatide's market share.

Potential construction delays in Indiana could affect GLP-1 drug production timelines.

Regulatory challenges may hinder Kisunla's expansion in new Alzheimer's markets.

Differentiation

Eli Lilly's rich history includes the first life-saving insulin treatment.

Lilly's strategic partnerships enhance its position in neurodegenerative disease treatments.

FDA approval of Zepbound opens new therapeutic markets for sleep disorder treatments.

Upsides

Lilly's $9 billion complex in Indiana boosts GLP-1 drug production capacity.

Kisunla's approval in China expands Lilly's Alzheimer's treatment market in Asia.

Collaboration with EVA Pharma enhances Lilly's reputation as socially responsible.

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