Advisor - Protein Engineering and CAR Design at Eli Lilly and Company

San Diego, California, United States

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Not SpecifiedCompensation

Mid-level (3 to 4 years), Senior (5 to 8 years)Experience Level

Full TimeJob Type

UnknownVisa

Biotechnology, PharmaceuticalsIndustries

Requirements

Ph.D. in protein engineering, protein biochemistry, structural biology, protein biophysics, molecular biology, or related field
Minimum 3 years of postdoctoral experience in CAR-T technologies
Strong foundation in protein structure and function, including demonstrated success in applying rational protein design and experimental approaches in affinity, function or stability engineering
Proficiency in computational tools for structure modeling and analysis (e.g., Rosetta, Schrödinger, Chimera, PyMOL, MOE, AlphaFold)
Hands-on experience in molecular biology

Responsibilities

Design, engineer, and optimize novel Chimeric Antigen Receptors (CAR’s) using a combination of structure-guided and experimental/library approaches to improve biological function, potency, time-action, stability, and immunogenicity profiles
Apply knowledge of protein structure–function relationships and structure–activity relationships (SAR) to guide molecular engineering efforts
Lead independent research projects from concept to execution, including critically analyzing experimental results, drawing appropriate conclusions and identifying new strategies to design and optimize novel biotherapeutics
Troubleshoot complex challenges in protein engineering and develop innovative solutions
Advance core capabilities in antibody and protein engineering and contribute to the development of new platform technologies
Serve as a protein engineering lead on cross-functional project teams, working closely with experts in computational biology, development, manufacturing, and translational teams
Present research findings at internal meetings and contribute to scientific publications and regulatory documents, as appropriate
Mentor junior scientists and research associates to support their technical development and career growth
Stay current with emerging scientific trends and maintain awareness of the competitive landscape in biologics discovery

Skills

protein engineering

CAR design

structural biology

biochemistry

molecular biology

protein therapeutics

bioconjugates

antibodies

developability

immunogenicity

Eli Lilly and Company

Develops and delivers prescription medicines globally

About Eli Lilly and Company

Eli Lilly and Company is a global pharmaceutical company that focuses on discovering, developing, and delivering medicines to improve health. The company has a long history of scientific achievements, including the creation of insulin, the first life-saving treatment for diabetes. Lilly's operations involve extensive research and development to create new medications and enhance existing ones, ensuring they are safe and effective. Their products are primarily prescription medicines sold to healthcare providers for various medical conditions, including diabetes, cancer, and pain management. What sets Lilly apart from its competitors is its strong commitment to ethical practices and the protection of its products from counterfeiting. The company's goal is to enhance lives through innovative medical solutions while maintaining high standards of quality and ethics.

Indianapolis, IndianaHeadquarters

1876Year Founded

$1,180.1MTotal Funding

IPOCompany Stage

Biotechnology, HealthcareIndustries

10,001+Employees

Risks

Competition from Novo Nordisk's Ozempic may impact tirzepatide's market share.

Potential construction delays in Indiana could affect GLP-1 drug production timelines.

Regulatory challenges may hinder Kisunla's expansion in new Alzheimer's markets.

Differentiation

Eli Lilly's rich history includes the first life-saving insulin treatment.

Lilly's strategic partnerships enhance its position in neurodegenerative disease treatments.

FDA approval of Zepbound opens new therapeutic markets for sleep disorder treatments.

Upsides

Lilly's $9 billion complex in Indiana boosts GLP-1 drug production capacity.

Kisunla's approval in China expands Lilly's Alzheimer's treatment market in Asia.

Collaboration with EVA Pharma enhances Lilly's reputation as socially responsible.

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