Advisor - Protein & CAR Construct Engineering at Eli Lilly and Company

San Diego, California, United States

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Not SpecifiedCompensation

Entry Level & New GradExperience Level

Full TimeJob Type

UnknownVisa

Biotechnology, Healthcare, PharmaceuticalsIndustries

Requirements

Ph.D. in Molecular Biology, Biochemistry, Bioengineering, Chemical Engineering, Immunology, or related discipline
Proven expertise in protein expression and purification across multiple systems (bacterial, yeast, mammalian, cell-free)
Preferred: Expertise in CAR-T
Preferred: Postdoctoral or industry experience in cell and gene therapy, immunotherapy, or protein therapeutics
Preferred: Deep understanding of protein structure-function relationships
Background in protein engineering and/or protein biochemistry
Sound practical knowledge of molecular biology

Responsibilities

Design, engineer, and optimize proteins for therapeutic applications using rational design, computational modeling, and directed evolution approaches
Conduct structure-function analyses to enhance protein stability, binding affinity, specificity, and therapeutic properties
Contribute to cross-functional project teams as protein engineering lead
Develop novel protein engineering strategies to address challenging therapeutic targets
Analyze and interpret complex datasets using bioinformatics and computational tools
Design and construct sophisticated CAR architectures incorporating various antigen-binding domains, costimulatory modules, and signaling elements
Engineer next-generation CAR platforms including multi-specific, switchable, and logic-gated constructs
Optimize CAR expression, cell surface presentation, and functional properties through iterative molecular engineering
Design and execute validation studies for CAR constructs in relevant cell-based functional assays
Contribute to intellectual property generation and patent applications
Independently design and execute experimental plans to address key research objectives
Troubleshoot complex technical challenges and develop innovative solutions
Mentor research associates and provide technical guidance
Author scientific manuscripts, technical reports, and regulatory documents
Present research findings at internal meetings and external scientific conferences
Collaborate with cross-functional teams including immunology, cell biology, analytics, and process development
Participate in project planning and contribute to research strategy development

Skills

Protein Engineering

CAR Construct Design

Rational Design

Computational Modeling

Directed Evolution

Protein Biochemistry

Molecular Biology

Structure/Function Relationships

Eli Lilly and Company

Develops and delivers prescription medicines globally

About Eli Lilly and Company

Eli Lilly and Company is a global pharmaceutical company that focuses on discovering, developing, and delivering medicines to improve health. The company has a long history of scientific achievements, including the creation of insulin, the first life-saving treatment for diabetes. Lilly's operations involve extensive research and development to create new medications and enhance existing ones, ensuring they are safe and effective. Their products are primarily prescription medicines sold to healthcare providers for various medical conditions, including diabetes, cancer, and pain management. What sets Lilly apart from its competitors is its strong commitment to ethical practices and the protection of its products from counterfeiting. The company's goal is to enhance lives through innovative medical solutions while maintaining high standards of quality and ethics.

Indianapolis, IndianaHeadquarters

1876Year Founded

$1,180.1MTotal Funding

IPOCompany Stage

Biotechnology, HealthcareIndustries

10,001+Employees

Risks

Competition from Novo Nordisk's Ozempic may impact tirzepatide's market share.

Potential construction delays in Indiana could affect GLP-1 drug production timelines.

Regulatory challenges may hinder Kisunla's expansion in new Alzheimer's markets.

Differentiation

Eli Lilly's rich history includes the first life-saving insulin treatment.

Lilly's strategic partnerships enhance its position in neurodegenerative disease treatments.

FDA approval of Zepbound opens new therapeutic markets for sleep disorder treatments.

Upsides

Lilly's $9 billion complex in Indiana boosts GLP-1 drug production capacity.

Kisunla's approval in China expands Lilly's Alzheimer's treatment market in Asia.

Collaboration with EVA Pharma enhances Lilly's reputation as socially responsible.

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