TSMS Lab Sr. Principal Process Scientist at Eli Lilly and Company

Lebanon, Indiana, United States

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Not SpecifiedCompensation

Senior (5 to 8 years), Expert & Leadership (9+ years)Experience Level

Full TimeJob Type

UnknownVisa

Pharmaceuticals, BiotechnologyIndustries

Requirements

Ph.D. in Organic Chemistry, Medicinal Chemistry, Chemical Engineering, or a related scientific discipline with a strong emphasis on peptide synthesis and purification
Minimum of 3 years of relevant experience in peptide process development within a pharmaceutical or biotechnology setting (post-doctoral experience will be considered)
Demonstrated expertise in both solid-phase and solution-phase peptide synthesis techniques
Proficiency in various preparative chromatography techniques, particularly HPLC and MPLC for peptide purification
Strong understanding of analytical techniques used for peptide characterization (LC-MS, NMR, UV-Vis, AAA, etc.)
Experience with process scale-up and technology transfer to manufacturing is highly desirable
Excellent problem-solving skills and a strong ability to work independently and as part of a team
Outstanding written and verbal communication skills, with the ability to present complex scientific information clearly and concisely
Familiarity with cGMP principles and quality systems is a plus

Responsibilities

Lead and execute laboratory-based research and development activities for the synthesis and/or purification of complex peptides, including solid-phase peptide synthesis (SPPS) and solution-phase peptide synthesis (LPPS)
Design and perform experiments for process optimization, including reaction conditions, reagent selection, purification strategies (e.g., HPLC, preparative chromatography), and yield improvement
Troubleshoot and resolve technical challenges related to peptide synthesis and/or purification, applying a deep understanding of organic chemistry and peptide chemistry principles
Collaborate cross-functionally with medicinal chemists, analytical chemists, process engineers, and manufacturing teams to ensure seamless technology transfer and scale-up of peptide processes
Document experimental procedures, results, and conclusions thoroughly in laboratory notebooks and technical reports
Present findings and recommendations to project teams and senior management
Stay abreast of the latest scientific advancements in peptide chemistry, synthesis technologies, and purification techniques
Contribute to the development of intellectual property and patent applications
Adhere to all safety regulations and good laboratory practices (GLP)

Skills

Key technologies and capabilities for this role

SPPSLPPSHPLCpreparative chromatographypeptide synthesispeptide purificationorganic chemistrypeptide chemistryprocess optimizationscale-up

Questions & Answers

Common questions about this position

What qualifications are required for the TSMS Lab Sr. Principal Process Scientist role?

A Ph.D. in Organic Chemistry, Medicinal Chemistry, Chemical Engineering, or a related field with emphasis on peptide synthesis and purification is required, along with at least 3 years of relevant experience in peptide process development in pharma or biotech, expertise in solid-phase and solution-phase synthesis, and proficiency in preparative chromatography like HPLC and MPLC.

What is the salary or compensation for this position?

This information is not specified in the job description.

Is this a remote position, or is there a location requirement?

This information is not specified in the job description.

What does Eli Lilly's company culture emphasize?

Eli Lilly unites caring with discovery to make life better for people, puts people first, and seeks determined individuals who give their best effort while contributing to communities through philanthropy and volunteerism.

What makes a strong candidate for this role?

Strong candidates will have a Ph.D. with peptide expertise, 3+ years in pharmaceutical peptide process development, hands-on experience in SPPS, LPPS, and purification techniques like HPLC, plus the ability to lead lab R&D, troubleshoot, and collaborate cross-functionally.

Eli Lilly and Company

Develops and delivers prescription medicines globally

About Eli Lilly and Company

Eli Lilly and Company is a global pharmaceutical company that focuses on discovering, developing, and delivering medicines to improve health. The company has a long history of scientific achievements, including the creation of insulin, the first life-saving treatment for diabetes. Lilly's operations involve extensive research and development to create new medications and enhance existing ones, ensuring they are safe and effective. Their products are primarily prescription medicines sold to healthcare providers for various medical conditions, including diabetes, cancer, and pain management. What sets Lilly apart from its competitors is its strong commitment to ethical practices and the protection of its products from counterfeiting. The company's goal is to enhance lives through innovative medical solutions while maintaining high standards of quality and ethics.

Indianapolis, IndianaHeadquarters

1876Year Founded

$1,180.1MTotal Funding

IPOCompany Stage

Biotechnology, HealthcareIndustries

10,001+Employees

Risks

Competition from Novo Nordisk's Ozempic may impact tirzepatide's market share.

Potential construction delays in Indiana could affect GLP-1 drug production timelines.

Regulatory challenges may hinder Kisunla's expansion in new Alzheimer's markets.

Differentiation

Eli Lilly's rich history includes the first life-saving insulin treatment.

Lilly's strategic partnerships enhance its position in neurodegenerative disease treatments.

FDA approval of Zepbound opens new therapeutic markets for sleep disorder treatments.

Upsides

Lilly's $9 billion complex in Indiana boosts GLP-1 drug production capacity.

Kisunla's approval in China expands Lilly's Alzheimer's treatment market in Asia.

Collaboration with EVA Pharma enhances Lilly's reputation as socially responsible.

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