Senior Scientist/Principal Scientist, Expression at Abata Therapeutics

Brisbane, California, United States

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Not SpecifiedCompensation

Senior (5 to 8 years), Expert & Leadership (9+ years)Experience Level

Full TimeJob Type

UnknownVisa

Biotechnology, PharmaceuticalsIndustries

Requirements

PhD with 8+ years of industry experience
Strong foundation in protein expression in eukaryotic, prokaryotic, and cell-free systems
Demonstrated expertise in cloning techniques for therapeutic protein development
Pharmaceutical or industrial experience in protein production at scales from microgram to gram
Strong understanding of biophysics of protein-protein interactions and protein chemistry
Extensive experience in molecular biology and biophysical techniques for protein engineering
Strong technical background in protein expression, tissue culture, aseptic techniques, and operation/maintenance of bioreactors in industry
Experienced molecular biologist able to design and make expression constructs
Mammalian transient protein expression and cell line generation
Hands-on experience in generating and managing research cell banks
Experience in protein purification and protein characterization
Experience in high throughput expression and purification (expected)
Experience and flexibility in downstream purification (required)
Supervisory or mentorship experience (desirable)
Ability to work independently, drive scientific execution, and provide technical leadership
Ability to collaborate in cross-functional teams
Strong communication skills and ability to present data to diverse audiences
Highly adaptable in fast-paced, matrixed environment
Excellent record keeping and organization

Responsibilities

Lead protein expression in multiple systems: mammalian, prokaryotic, insect, and cell-free
Perform downstream processing: harvesting cells (small scale to 20L) using depth filters, affinity chromatography, ion exchange chromatography, and sizing
Use analytical techniques to evaluate process efficiency and quality
Develop creative approaches: construct design/screening for higher yields, novel strategies for difficult proteins, and stability improvements
Work on target proteins: therapeutic proteins, antigens, assay reagents, and proteins for structural studies
Provide leadership and mentoring to team members

Skills

Key technologies and capabilities for this role

Protein ExpressionCloningEukaryotic ExpressionProkaryotic ExpressionCell-Free ExpressionProtein EngineeringMolecular BiologyBiophysical TechniquesProtein ChemistryProtein-Protein Interactions

Questions & Answers

Common questions about this position

What experience is required for the Senior/Principal Scientist role?

Candidates need a strong foundation in protein expression in eukaryotic, prokaryotic, and cell-free systems, with demonstrated expertise in cloning techniques, plus pharmaceutical or industrial experience in protein production from microgram to gram scales.

What are the key responsibilities of this position?

Primary responsibilities include protein expression in mammalian, prokaryotic, insect, and cell-free systems, downstream processing up to 20L scale using techniques like affinity chromatography, and using analytical methods to evaluate efficiency, with creative approaches for improving yields and stability.

Is this a remote position or does it require on-site work?

This information is not specified in the job description.

What is the salary or compensation for this role?

This information is not specified in the job description.

What makes a strong candidate for this scientist position?

Strong candidates have expertise in biophysics of protein-protein interactions, protein chemistry, molecular biology techniques, supervisory experience, collaboration skills, strong communication, and adaptability in a fast-paced environment.

Abata Therapeutics

Develops therapies for autoimmune diseases

About Abata Therapeutics

Abata Therapeutics develops therapies for autoimmune diseases, focusing on type 1 diabetes. Their main product, ABA 201, is a Treg cell therapy aimed at patients with some remaining beta cell function. This therapy works by utilizing regulatory T cells to improve patient outcomes. Unlike many competitors, Abata targets a specific niche within the autoimmune disease market and collaborates with partners like ElevateBio for process development and manufacturing. The company's goal is to transform treatment options for autoimmune diseases through advanced research and development.

Cambridge, MassachusettsHeadquarters

2021Year Founded

$184.8MTotal Funding

EARLY_VCCompany Stage

BiotechnologyIndustries

11-50Employees

Risks

Intensifying competition from companies like Sangamo Therapeutics may impact Abata's market share.

Stringent FDA scrutiny on manufacturing could delay Abata's clinical trials.

Rising clinical trial costs pose financial risks to Abata's pipeline progression.

Differentiation

Abata focuses on Treg cell therapies for autoimmune diseases like MS and diabetes.

Their lead product, ABA 201, targets type 1 diabetes with remaining beta cell function.

Abata's strategic partnership with ElevateBio enhances their manufacturing capabilities.

Upsides

Recent investment from Bristol Myers Squibb boosts Abata's Treg therapy pipeline development.

FDA's accelerated approval pathways may expedite Abata's clinical trials.

Growing autoimmune disease prevalence increases demand for Abata's innovative treatments.

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