Senior Scientist, Preclinical Safety & Translational Sciences – Translational PK at Johnson & Johnson

San Diego, California, United States

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Not SpecifiedCompensation

Senior (5 to 8 years)Experience Level

Full TimeJob Type

UnknownVisa

Pharmaceuticals, Biotechnology, HealthcareIndustries

Requirements

Bachelor's degree in Biomedical Science, Pharmaceutical Science, or a relevant Life Sciences field (minimum required); advanced degree (Master's, PhD) highly preferred
For Bachelor's: Minimum of 6 years of relevant industry experience
For Master's: Minimum of 4 years of relevant industry experience
For PhD: Minimum of 2 years of relevant experience, including PhD, postdoc, or industry experience
Postdoctoral research or experience

Responsibilities

Independently designing, performing, and managing various in vitro screening and mechanistic ADME studies to address specific DMPK questions in drug discovery
Developing analytical methods using mass spectrometry (LC-MS/MS and HRMS) to separate and detect small molecules and other modalities
Analyzing and interpreting experimental data
Preparing and delivering scientific presentations and reports to communicate research results within and outside the TPPIT department
Maintaining current knowledge of relevant scientific literature and evaluating implications for internal projects
Maintaining laboratory equipment as well as clear, detailed, and up-to-date experimental records
Designing and completing in vitro screening and mechanistic ADME studies to enable comprehensive PK/PD and safety characterization of small molecules and other modalities such as molecular glues and PROTACs
Establishing workflows to support the ADME characterization of drug candidates by establishing next generation complex in vitro models
Authoring reports and scientific publications and presenting data to the scientific community both internally and externally

Skills

Key technologies and capabilities for this role

ADMEPharmacokineticsPharmacodynamicsIn Vitro ScreeningToxicokineticsInvestigative ToxicologyPK/PDTranslational Sciences

Questions & Answers

Common questions about this position

Is this position remote or onsite?

The position is located in La Jolla, CA, requiring onsite work in San Diego, California.

What are the key responsibilities of this role?

The role involves independently designing, performing, and managing in vitro screening and mechanistic ADME studies, developing analytical methods using mass spectrometry (LC-MS/MS and HRMS), and supporting ADME characterization of drug candidates including small molecules, molecular glues, and PROTACs.

What skills and experience are required for this Senior Scientist position?

Candidates need expertise in designing and conducting in vitro ADME studies, developing LC-MS/MS and HRMS analytical methods, and experience with small molecules, molecular glues, and PROTACs. Hands-on lab work and the ability to author reports and present data are also essential.

What is the company culture like at Johnson & Johnson Innovative Medicine?

The culture emphasizes patient-inspired science-based advancements, teamwork to develop life-saving medicines, and innovation from lab to life while championing patients.

What makes a strong candidate for this Senior Scientist role?

A highly motivated scientist with hands-on experience in ADME studies, mass spectrometry, and novel modalities like PROTACs, who can independently design experiments, author publications, and present data internally and externally.

Johnson & Johnson

Healthcare products in pharmaceuticals and devices.

About Johnson & Johnson

Johnson & Johnson operates in the healthcare sector with three main areas: pharmaceuticals, medical devices, and consumer health products. In the pharmaceuticals segment, the company develops prescription drugs for various medical conditions such as cancer and infectious diseases. The medical devices segment provides products used in surgeries and other medical procedures, while the consumer health segment offers over-the-counter products, including baby care and personal health items. Johnson & Johnson generates revenue through direct sales and partnerships, and it invests significantly in research and development to create new products that meet the needs of consumers and healthcare providers. The company stands out from competitors by emphasizing diversity, equity, and inclusion in its workplace, fostering an environment where employees can share their perspectives. Its goal is to improve patient outcomes and enhance the overall health and well-being of individuals globally.

New Brunswick, New JerseyHeadquarters

1886Year Founded

IPOCompany Stage

HealthcareIndustries

10,001+Employees

Risks

J&J faces a class action lawsuit in Australia over ineffective cold and flu medications.

Former J&J executives joining other firms could lead to increased competition.

Ongoing legal battles, like the lawsuit against Cigna, pose financial liabilities for J&J.

Differentiation

J&J operates in three segments: pharmaceuticals, medical devices, and consumer health.

The company invests heavily in R&D for innovative medical solutions and products.

J&J is committed to diversity, equity, and inclusion in its workplace culture.

Upsides

J&J's collaboration with Helsinki University Hospital focuses on value-based healthcare models.

The rise of personalized medicine offers J&J opportunities in targeted therapies.

Increased focus on digital health solutions presents expansion opportunities for J&J.

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