Senior/Principal Scientist, Medicinal Chemistry at Abata Therapeutics

Berkeley, California, United States

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Not SpecifiedCompensation

Senior (5 to 8 years), Expert & Leadership (9+ years)Experience Level

Full TimeJob Type

UnknownVisa

Biotechnology, Pharmaceuticals, Oncology, ImmunologyIndustries

Requirements

Excellent knowledge of medicinal chemistry principles, physicochemical properties of drug-like matter, ability to solve ADME and DMPK challenges
Strong working knowledge of protein-ligand interactions, and conformational and structural analysis
Experience in partnering closely with computational chemists utilizing computational tools, models, and visualization applications
Broad range of organic chemistry knowledge
Planning and performing complex multi-step organic syntheses, retro-synthetic analysis
Extensive repertoire of classic and modern reactions including transition metal catalysis
Strong communication skills, work ethic, enthusiasm, and self-starter mentality
Creative problem solver in the face of synthesis and project difficulties
Ability to work collaboratively in a fast-paced, team environment with rapidly changing priorities
Excellent planning, organization, and time management skills
Highly goal-driven and detail-oriented; commitment to continuous learning
Record of achievement with peer-reviewed publications

Responsibilities

Design novel bioactive molecules to generate and drive SAR
Apply medicinal chemistry principles to improve protein-ligand interactions, address ADME issues, and optimize DMPK properties
Understand goals & strategies of the project, proactively develop innovative & practical chemistry
Independently plan, initiate and efficiently execute the synthesis, purification, and characterization of small molecules
Sustain a high level of productivity in the lab delivering on team goals
Analyze data, interpret, and communicate results as part of an internal multi-disciplinary team
Maintain broad knowledge of state-of-the-art principles and theories related to synthetic organic chemistry, keep abreast of recent scientific developments, patents, and primary literature
Prepare presentation materials, clearly communicate research results at meetings to the Chemistry Department and cross-functional teams
Manage a team of CRO chemists incl. attending a weekly TC
Participate in the development and writing of patent applications and scientific papers
Maintain a detailed laboratory notebook according to corporate standards and SOPs
Assume instrument stewardships (e.g. LCMS, NMR, Lyophilizer etc.)
Keep laboratory environment safe and well-organized, abiding by all regulatory guidelines

Skills

Medicinal Chemistry

SAR Analysis

Organic Synthesis

Hit-to-Lead

Lead Optimization

ADME

DMPK

CRO Management

Abata Therapeutics

Develops therapies for autoimmune diseases

About Abata Therapeutics

Abata Therapeutics develops therapies for autoimmune diseases, focusing on type 1 diabetes. Their main product, ABA 201, is a Treg cell therapy aimed at patients with some remaining beta cell function. This therapy works by utilizing regulatory T cells to improve patient outcomes. Unlike many competitors, Abata targets a specific niche within the autoimmune disease market and collaborates with partners like ElevateBio for process development and manufacturing. The company's goal is to transform treatment options for autoimmune diseases through advanced research and development.

Cambridge, MassachusettsHeadquarters

2021Year Founded

$184.8MTotal Funding

EARLY_VCCompany Stage

BiotechnologyIndustries

11-50Employees

Risks

Intensifying competition from companies like Sangamo Therapeutics may impact Abata's market share.

Stringent FDA scrutiny on manufacturing could delay Abata's clinical trials.

Rising clinical trial costs pose financial risks to Abata's pipeline progression.

Differentiation

Abata focuses on Treg cell therapies for autoimmune diseases like MS and diabetes.

Their lead product, ABA 201, targets type 1 diabetes with remaining beta cell function.

Abata's strategic partnership with ElevateBio enhances their manufacturing capabilities.

Upsides

Recent investment from Bristol Myers Squibb boosts Abata's Treg therapy pipeline development.

FDA's accelerated approval pathways may expedite Abata's clinical trials.

Growing autoimmune disease prevalence increases demand for Abata's innovative treatments.

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