Senior Computational Biologist (Remote)
Output BiosciencesFull Time
Expert & Leadership (9+ years)
Toronto, Ontario, Canada
Candidates must possess an MS or PhD in bioinformatics, computational biology, or a related field, with at least 3 years of post-graduation experience, preferably in an industry setting. Essential qualifications include solid Python programming skills, experience working with large genomics data, particularly single-cell genomics data, and familiarity with Linux-based operating systems. Experience in an HPC environment, preferably AWS cloud, is also required. Desirable qualifications include familiarity with pipeline workflow languages like Metaflow or Snakemake, experience with containerization using Docker, and familiarity with R.
The Senior Bioinformatician will be responsible for primary and secondary analysis of single-cell datasets, including read alignment and quality control. They will collaborate with wet-lab scientists to design experiments, troubleshoot data quality, and ensure smooth data handoff. This role involves developing data processing pipelines for single-cell sequencing and other high-throughput genomics assays, and partnering with software engineers to scale workflows in cloud environments. Responsibilities also include ensuring reproducibility through containerization and pipeline orchestration, and communicating results and insights to cross-functional teams. Staying current with advances in single-cell modalities and computational methods is also a key responsibility.
Develops therapies for autoimmune diseases
Abata Therapeutics develops therapies for autoimmune diseases, focusing on type 1 diabetes. Their main product, ABA 201, is a Treg cell therapy aimed at patients with some remaining beta cell function. This therapy works by utilizing regulatory T cells to improve patient outcomes. Unlike many competitors, Abata targets a specific niche within the autoimmune disease market and collaborates with partners like ElevateBio for process development and manufacturing. The company's goal is to transform treatment options for autoimmune diseases through advanced research and development.