Scientist, Preclinical Safety & Translational Sciences -Translational PK at Johnson & Johnson

San Diego, California, United States

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Not SpecifiedCompensation

Mid-level (3 to 4 years), Senior (5 to 8 years)Experience Level

Full TimeJob Type

UnknownVisa

Pharmaceuticals, Biotechnology, HealthcareIndustries

Requirements

Bachelor's degree in Biomedical Science, Pharmaceutical Science or a relevant Life Sciences field (required); advanced degree (Master's) highly preferred
Minimum of 3+ years of relevant experience (or 2+ years with Master's degree)
Experience with designing, performing, and interpreting a broad range of in vitro ADME assays such as metabolic stability, DDI, CYP inhibition, CYP induction, plasma protein or tissue binding assays

Responsibilities

Independently designing, performing, and managing various in vitro screening and mechanistic ADME studies to address specific DMPK questions in drug discovery
Developing analytical methods using mass spectrometry (LC-MS/MS and HRMS) to separate and detect small molecules and other modalities
Analyzing and interpreting experimental data
Preparing and delivering scientific presentations and reports to communicate research results within and outside the TPPIT department
Maintaining current knowledge of relevant scientific literature and evaluating implications for internal projects
Maintaining laboratory equipment as well as clear, detailed, and up-to-date experimental records

Skills

Key technologies and capabilities for this role

ADMEPharmacokineticsPharmacodynamicsIn Vitro ScreeningToxicokineticsInvestigative ToxicologyPK/PDTranslational Sciences

Questions & Answers

Common questions about this position

Is this position remote or onsite?

The position is located in La Jolla, CA, requiring onsite work in San Diego, California.

What are the key responsibilities of this role?

The role involves independently designing, performing, and managing in vitro screening and mechanistic ADME studies, developing analytical methods using mass spectrometry like LC-MS/MS and HRMS, and supporting ADME characterization of drug candidates including small molecules, molecular glues, and PROTACs.

What skills or experience are required for this Scientist position?

Hands-on experience with in vitro ADME studies, mechanistic studies, and analytical method development using mass spectrometry (LC-MS/MS and HRMS) is essential, along with the ability to design studies for small molecules, molecular glues, and PROTACs.

What is the company culture like at Johnson & Johnson Innovative Medicine?

The culture emphasizes patient-inspired science-based advancements, teamwork with visionaries to develop life-saving medicines, and a commitment to innovation from lab to life while championing patients.

What makes a strong candidate for this Translational PK Scientist role?

A highly motivated scientist with hands-on lab experience in ADME studies and mass spectrometry, capable of independent study design and management, and interested in personal growth through training, mentoring, and contributing to J&J's discovery programs.

Johnson & Johnson

Healthcare products in pharmaceuticals and devices.

About Johnson & Johnson

Johnson & Johnson operates in the healthcare sector with three main areas: pharmaceuticals, medical devices, and consumer health products. In the pharmaceuticals segment, the company develops prescription drugs for various medical conditions such as cancer and infectious diseases. The medical devices segment provides products used in surgeries and other medical procedures, while the consumer health segment offers over-the-counter products, including baby care and personal health items. Johnson & Johnson generates revenue through direct sales and partnerships, and it invests significantly in research and development to create new products that meet the needs of consumers and healthcare providers. The company stands out from competitors by emphasizing diversity, equity, and inclusion in its workplace, fostering an environment where employees can share their perspectives. Its goal is to improve patient outcomes and enhance the overall health and well-being of individuals globally.

New Brunswick, New JerseyHeadquarters

1886Year Founded

IPOCompany Stage

HealthcareIndustries

10,001+Employees

Risks

J&J faces a class action lawsuit in Australia over ineffective cold and flu medications.

Former J&J executives joining other firms could lead to increased competition.

Ongoing legal battles, like the lawsuit against Cigna, pose financial liabilities for J&J.

Differentiation

J&J operates in three segments: pharmaceuticals, medical devices, and consumer health.

The company invests heavily in R&D for innovative medical solutions and products.

J&J is committed to diversity, equity, and inclusion in its workplace culture.

Upsides

J&J's collaboration with Helsinki University Hospital focuses on value-based healthcare models.

The rise of personalized medicine offers J&J opportunities in targeted therapies.

Increased focus on digital health solutions presents expansion opportunities for J&J.

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