Research Scholar, Technology Development & Translational Genomics (Immunogenomics Group - Biohub NY) at Chan Zuckerberg Biohub

New York, New York, United States

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Not SpecifiedCompensation

Senior (5 to 8 years), Expert & Leadership (9+ years)Experience Level

Full TimeJob Type

UnknownVisa

Biotechnology, Genomics, ImmunologyIndustries

Requirements

Expertise in immunology, cancer biology, and functional genomics
Experience with genomic technologies including single-cell nascent RNA sequencing (scGRO-seq), ATAC-seq, epigenomic profiling, single-cell and spatial transcriptomics
Skills in computational analysis integrating machine learning and AI to map enhancer–gene networks
Familiarity with genome editing, immune engineering, CRISPR-based functional screens, patient biopsies, organoid systems, and mouse models
Ability to lead an interdisciplinary research program with substantial independence in project design
Capacity to contribute to high-impact publications, translational discoveries, and mentoring junior scientists

Responsibilities

Map regulatory elements: Define active enhancers and other regulatory regions altered by stress, inflammation, and trauma exposures using single-cell nascent RNA sequencing (scGRO-seq), ATAC-seq, and complementary epigenomic profiling approaches
Profile immune states: Characterize immune cell states and transcriptional programs associated with stress- and inflammation-induced memory through single-cell and spatial transcriptomics, complemented by functional assays of cytokine production, cytotoxicity, and antigen presentation
Dissect mechanisms of immune memory: Investigate enhancer–gene networks and transcriptional machinery that encode and sustain immunosuppressive programs across lymphoid, myeloid, and stromal cell populations
Employ genetically engineered and inducible inflammation models (e.g., caerulein-induced pancreatitis) to probe persistence and functional consequences of transcriptional changes
Lead an interdisciplinary research program at the intersection of immunology, cancer biology, and functional genomics, focusing on decoding molecular 'memory' in the genome from inflammation, stress, and lived experiences
Work with cutting-edge genomic technologies, advanced disease models, and patient-derived samples to discover and characterize disease-driving regulatory elements and develop targeted interventions
Shape a new research direction within the lab, collaborate across computational biology, epigenetics, immunotherapy, and clinical research, and mentor junior scientists

Skills

Key technologies and capabilities for this role

CRISPRsingle-cell RNA sequencingnascent RNA sequencinggenome editingimmune engineeringmachine learningAI

Questions & Answers

Common questions about this position

What is the salary for the Research Scholar position?

This information is not specified in the job description.

Is this Research Scholar role remote or onsite?

This information is not specified in the job description.

What skills and expertise are required for this Research Scholar position?

The role requires expertise at the intersection of immunology, cancer biology, and functional genomics, with a focus on non-coding regulatory genome, enhancers, genomic technologies like single-cell sequencing, genome editing, CRISPR screens, and computational analysis using machine learning and AI.

What is the company culture like at CZ Biohub New York?

The culture emphasizes diversity of thought, ideas, and perspectives to enable disruptive innovation and scholarly excellence, with a commitment to making all colleagues feel inspired and that their work makes an important contribution. They pursue large scientific challenges, enable risky and innovative ideas, and foster collaboration across computational biology, epigenetics, immunotherapy, and clinical research.

What makes a strong candidate for this Research Scholar role?

A strong candidate will have the ability to lead an independent interdisciplinary research program on immune dysfunction and genomic 'memory' in diseases like cancer, with experience in cutting-edge genomic technologies, disease models, and patient samples, and a drive to shape new research directions for high-impact publications.

Chan Zuckerberg Biohub

Nonprofit research center for disease understanding

About Chan Zuckerberg Biohub

The Chan Zuckerberg Biohub focuses on biomedical research and technology development. It collaborates with top universities to study the basic mechanisms of diseases and create new diagnostic tools and therapies. The Biohub combines the expertise of engineers, data scientists, and researchers to tackle complex health challenges. Unlike many research institutions, it emphasizes a collaborative approach, pooling resources and knowledge from multiple prestigious universities. The goal of the Chan Zuckerberg Biohub is to advance scientific understanding and improve health outcomes through innovative research.

San Francisco, CaliforniaHeadquarters

2016Year Founded

VENTURE_UNKNOWNCompany Stage

Data & Analytics, BiotechnologyIndustries

51-200Employees

Benefits

Health Insurance

Life Insurance

Disability Insurance

401(k) Company Match

Family Planning Benefits

Fertility Treatment Support

Childcare Support

Unlimited Paid Time Off

Paid Vacation

Risks

Expansion may strain resources and management capabilities.

Potential ethical concerns with AI model reliance.

Collaboration with multiple universities could lead to intellectual property disputes.

Differentiation

CZ Biohub unites top universities for collaborative biomedical research.

Focus on AI-driven models for disease detection and treatment.

Pioneering cellular endoscopes for early disease monitoring and intervention.

Upsides

Expansion into New York enhances collaboration with leading institutions.

AI initiatives align with growing trends in drug discovery and precision medicine.

Genomic training initiatives support underrepresented medical students.

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