Principal Scientist - In-vitro Display at Eli Lilly and Company

San Diego, California, United States

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Not SpecifiedCompensation

Senior (5 to 8 years), Expert & Leadership (9+ years)Experience Level

Full TimeJob Type

UnknownVisa

Biotechnology, PharmaceuticalsIndustries

Requirements

B.S./M.S. in a relevant field with at least 6+ years industry experience in molecular biology, biochemistry, or protein engineering
Proven hands-on experience with fundamental biology techniques, including: cell culture, viability assays, transfections, Western blot, affinity assays, image-based assays
Strong experience in molecular biology including standard cloning techniques, sequence analysis, DNA and RNA extraction, ligation, PCR
Hands-on experience with flow cytometry
Experience in tissue culture
Understanding of biochemistry and molecular biology especially pertaining to techniques for protein engineering
Excellent communication skills with a desire to be involved in collaborative, cross-functional teams

Responsibilities

Discover, engineer, and optimize antibodies using in vitro display technologies to improve biological function, developability, and immunogenicity profiles
Use biochemical and functional assays to evaluate antibody-antigen interaction including ELISA, cell binding and signaling assays, Octet or other SPR-based techniques
Demonstrate strong expertise in molecular and cellular biology techniques including western blotting, PCR, cell culture, and site-directed mutagenesis
Set up and execute experiments
Perform data analysis and troubleshooting
Prepare and present data at lab meetings

Skills

Key technologies and capabilities for this role

flow cytometrytissue cultureprotein engineeringantibody discoveryin vitro displayrecombinant antibody expressionantibody characterizationbiochemistrymolecular biologydata analysis

Questions & Answers

Common questions about this position

What qualifications are required for the Principal Scientist role?

A B.S./M.S. in a relevant field with at least 6+ years of industry experience in molecular biology, biochemistry, or protein engineering is required.

What key skills and experiences are needed for this position?

Hands-on experience with flow cytometry, tissue culture, biochemistry, and molecular biology techniques for protein engineering is required, along with skills in cell culture, viability assays, transfections, Western blot, affinity assays, cloning, and sequence analysis.

What are the main responsibilities of this role?

The role involves discovering, engineering, and optimizing antibodies using in vitro display technologies, using biochemical and functional assays to evaluate interactions, and demonstrating expertise in molecular and cellular biology techniques.

Is this a remote position or does it require working in an office?

This information is not specified in the job description.

What is the salary or compensation for this position?

This information is not specified in the job description.

Eli Lilly and Company

Develops and delivers prescription medicines globally

About Eli Lilly and Company

Eli Lilly and Company is a global pharmaceutical company that focuses on discovering, developing, and delivering medicines to improve health. The company has a long history of scientific achievements, including the creation of insulin, the first life-saving treatment for diabetes. Lilly's operations involve extensive research and development to create new medications and enhance existing ones, ensuring they are safe and effective. Their products are primarily prescription medicines sold to healthcare providers for various medical conditions, including diabetes, cancer, and pain management. What sets Lilly apart from its competitors is its strong commitment to ethical practices and the protection of its products from counterfeiting. The company's goal is to enhance lives through innovative medical solutions while maintaining high standards of quality and ethics.

Indianapolis, IndianaHeadquarters

1876Year Founded

$1,180.1MTotal Funding

IPOCompany Stage

Biotechnology, HealthcareIndustries

10,001+Employees

Risks

Competition from Novo Nordisk's Ozempic may impact tirzepatide's market share.

Potential construction delays in Indiana could affect GLP-1 drug production timelines.

Regulatory challenges may hinder Kisunla's expansion in new Alzheimer's markets.

Differentiation

Eli Lilly's rich history includes the first life-saving insulin treatment.

Lilly's strategic partnerships enhance its position in neurodegenerative disease treatments.

FDA approval of Zepbound opens new therapeutic markets for sleep disorder treatments.

Upsides

Lilly's $9 billion complex in Indiana boosts GLP-1 drug production capacity.

Kisunla's approval in China expands Lilly's Alzheimer's treatment market in Asia.

Collaboration with EVA Pharma enhances Lilly's reputation as socially responsible.

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