Principal Scientist at Bristol-Myers Squibb

Winter Garden, Florida, United States

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Not SpecifiedCompensation

Senior (5 to 8 years), Expert & Leadership (9+ years)Experience Level

Full TimeJob Type

UnknownVisa

Biotechnology, PharmaceuticalIndustries

Requirements

Bachelor's Degree with 8+ years of academic/industry experience, or Master's Degree with 6+ years of academic/industry experience, or PhD with 4+ years of academic/industry experience
Preferred: PhD from a recognized institution in a quantitative field such as computational biology, computational genomics/genetics, computer science, statistics, mathematics, or related discipline, with 5+ years of post-graduate experience
Advanced hands-on knowledge of at least one high-level programming language such as R or Python for computational research and reproducible research practices
Preferred: 5+ years of post-graduate experience in computational biology research (biopharma industry preferred) with track record (e.g., scientific publications) in driving and advancing research projects/programs with computational approaches
Hands-on experience analyzing and integrating high-dimensional molecular datasets such as multi-omics (RNA-seq, ATAC-seq, proteomics, ChIP-seq/CUT&RUN), single cell (CITE-seq, scATAC-seq, perturb-seq), and spatial profiling (Visium, GeoMx, CosMX)
Experience implementing and/or developing statistical methodologies and machine learning algorithms applied to biological problems
Background in Neuroscience, especially in neurodegenerative diseases, strongly preferred
Experience applying computer vision models to cellular imaging (preferred)

Responsibilities

Perform computational research on high-dimensional readouts from perturbation experiments/screens (e.g., CRISPR screens, perturb-seq, cellular imaging)
Apply machine learning and other advanced computational approaches to compare high-dimensional experimental readouts to disease states defined by patient data (including transcriptomics, proteomics, single cell omics, and imaging)
Work as part of a cross-functional team that will nominate and validate new targets for neurodegeneration and neuropsychiatry
Work with external partners in industry, academia, and pre-competitive collaborations (e.g., NIH Accelerating Medicines Partnership) on novel computational and experimental approaches
Communicate findings and recommend follow-up actions in multiple settings (including 1:1, seminars, and team meetings)

Skills

single cell

multi-omics

spatial profiling

gene perturbation

CRISPR screens

perturb-seq

cellular imaging

machine learning

Bristol-Myers Squibb

Develops and delivers biopharmaceutical medicines

About Bristol-Myers Squibb

Bristol Myers Squibb (BMS) develops and delivers medicines aimed at treating serious diseases, focusing on areas like cancer, autoimmune diseases, and heart conditions. The company conducts extensive research and development to create new drugs, which are sold after receiving regulatory approval. BMS also produces generic drugs, offering affordable alternatives that meet the same quality standards as their branded counterparts. What sets BMS apart from competitors is its dual focus on both innovative and generic medicines, enhancing access to healthcare. The company's goal is to improve patient outcomes while maintaining a commitment to sustainability and corporate responsibility.

New York City, New YorkHeadquarters

1887Year Founded

$33,706.1MTotal Funding

IPOCompany Stage

Biotechnology, HealthcareIndustries

10,001+Employees

Benefits

Flexible Work Hours

Hybrid Work Options

Professional Development Budget

Risks

Increased competition in oncology from emerging biotech firms like ArsenalBio.

BMS's lawsuit over the 340B Drug Pricing Program may lead to regulatory challenges.

Rapid AI and digital tech evolution may pose integration challenges for BMS.

Differentiation

BMS focuses on innovative cancer treatments through collaborations like ArsenalBio for T cell therapies.

The company emphasizes digital health technologies, enhancing clinical trial management and patient engagement.

BMS offers both innovative and generic medicines, increasing affordable healthcare solutions.

Upsides

BMS's partnership with Medidata enhances clinical research processes and patient outcomes.

The collaboration with AI Proteins advances novel miniprotein-based therapeutics, expanding therapeutic modalities.

BMS's global license agreement with BioArctic expands its portfolio in neurodegenerative diseases.

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