Post Doc Scientist (Computational & Structural Bioinformatics) at Gilead Sciences

Foster City, California, United States

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Not SpecifiedCompensation

Internship, Junior (1 to 2 years)Experience Level

Full TimeJob Type

UnknownVisa

Biotechnology, PharmaceuticalsIndustries

Requirements

Ph.D. in Computational Biology, Bioinformatics, Structural Biology, Biophysics, or related fields
At least one first-author publication in a peer-reviewed journal
Strong Python programming skills with extensive experience using scientific libraries (e.g., NumPy, SciPy, pandas) and deep learning frameworks including PyTorch and TensorFlow
Expertise in protein modeling tools (AlphaFold, RFDiffusion, Rosetta, PyMOL, etc.)
Hands-on experience with molecular dynamics packages (AMBER, GROMACS, etc.) is a plus
Familiarity with antibody structure and protein engineering principles
Proficiency in Linux environments and deploying workflows on HPC clusters
Excellent problem-solving and communication skills
Preferred Qualifications
Experience with graph neural networks, diffusion models, or generative frameworks for antibody design and optimization
Knowledge of enhanced sampling techniques (Metadynamics, Umbrella sampling)
Understanding binding thermodynamics and free energy calculations
Experience and/or familiarity with approaches for affinity validation and screening in the lab (e.g., high throughput recombinant protein production, EL)

Responsibilities

Develop advanced computational workflows for protein modeling, structural analysis, and molecular simulations
Apply machine learning and physics-based approaches to predict and optimize protein-protein interactions
Analyze large-scale biological datasets to uncover insights that guide experimental design
Validate computational predictions and generate critical training datasets in the lab
Optimize automated cloud-based pipelines for large-scale predictions and data processing
Publish and present your findings at top-tier conferences and journals

Skills

Computational Biology

Structural Bioinformatics

Protein-Protein Interactions

Physics-Based Modeling

Machine Learning

Protein Design

Antibody Design

Experimental Validation

Gilead Sciences

Develops and commercializes biopharmaceuticals

About Gilead Sciences

Gilead Sciences focuses on discovering, developing, and commercializing medicines for various medical conditions, including HIV/AIDS, liver diseases, cancer, inflammatory and respiratory diseases, and cardiovascular issues. The company conducts extensive research and development to create new therapies, which are then marketed to healthcare providers, hospitals, and pharmacies after receiving regulatory approval. Gilead differentiates itself from competitors through its strong commitment to R&D and strategic partnerships, such as with SAP Ariba, to enhance its operations and product offerings. The company's goal is to improve health equity and access to care globally, working with communities to ensure that its medicines reach those in need.

Foster City, CaliforniaHeadquarters

1987Year Founded

$15,873.6MTotal Funding

IPOCompany Stage

Biotechnology, HealthcareIndustries

10,001+Employees

Benefits

Paid family time off and paid parental time off

Generous 401(k) contribution matching

Comprehensive medical plans that cover both physical and mental healthcare

Global Wellbeing Reimbursement

Time Off

Global Volunteer Day

Giving Together Program

Employee Support Programs

Flexible Work Options

Risks

Increased competition in HIV treatment from ViiV Healthcare's expanding drug portfolio.

Regulatory scrutiny over drug pricing could impact Gilead's U.S. market operations.

Patent expirations, like Truvada's, lead to increased generic competition and revenue loss.

Differentiation

Gilead's lenacapavir is recognized as the 2024 Breakthrough of the Year for HIV care.

Partnerships with LEO Pharma and Tubulis enhance Gilead's focus on inflammatory and cancer therapies.

Gilead's commitment to health equity initiatives like COMPASS and HepConnect sets it apart.

Upsides

Gilead's strategic partnerships expand its reach in inflammatory and oncology drug markets.

Investment in digital health technologies enhances Gilead's R&D and patient engagement.

Focus on sustainability improves Gilead's operational efficiency and corporate reputation.

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