Manager, Clinical Sciences at Tango Therapeutics

Boston, Massachusetts, United States

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Not SpecifiedCompensation

Mid-level (3 to 4 years), Senior (5 to 8 years)Experience Level

Full TimeJob Type

UnknownVisa

Biotechnology, Oncology, Precision MedicineIndustries

Requirements

MS, PharmD, PhD, RN, or PA degree in a relevant scientific or clinical discipline
At least 5 years’ experience in clinical science, or research
At least 2 years’ experience in oncology
Understanding of clinical trial design, regulatory guidelines (FDA/ICH), and GCP principles
Strong analytical skills with proficiency in interpretation of clinical data and identification of clinical trends
Excellent written and oral communication skills, with the ability to convey complex scientific concepts clearly
Proven success operating in a high pace, dynamic team setting
Collaborative mindset with eagerness to learn and grow within clinical development

Responsibilities

Support the clinical development of investigational oncology therapies by contributing to study design discussions, including patient population definitions, endpoint selection, protocol feasibility assessments, and literature research of medical publications to extract data and relevant scientific information
Partner with cross-functional teams to support the timely start-up and execution of clinical trials in accordance with regulatory requirements and Good Clinical Practice (GCP)
Collaborate with data management, clinical operations, biostatistics, pharmacovigilance, and other clinical teams to ensure alignment on study milestones and deliverables
Contribute to the development and review of clinical documents including protocols, informed consent forms, Investigator's Brochures, clinical study reports, and regulatory submission materials
Assist with reviewing and writing other clinical trial documents and publications as needed
Conduct targeted literature reviews and extract relevant data from medical publications to support clinical development strategy and regulatory submissions
Provide clinical and scientific support to clinical sites and CROs, including assistance with protocol training, site communications, and query resolution
Review clinical data in EDC systems including data cleaning, to identify safety signals and trends, summarize findings, and contribute to interim data reviews and study decision making
Collaborate with data management to develop and maintain clinical data review plans, including defining data review schedules, identifying critical data points for monitoring, and establishing processes for ongoing data quality oversight
Prepare clear, concise data summaries and study status updates for internal team meetings and cross-functional review
Perform other related duties and responsibilities as assigned

Skills

Key technologies and capabilities for this role

Clinical DevelopmentStudy DesignProtocol DevelopmentGCPRegulatory SubmissionsClinical TrialsOncologyData ManagementBiostatisticsPharmacovigilanceInvestigator's BrochureClinical Study Reports

Questions & Answers

Common questions about this position

What qualifications are required for the Manager, Clinical Sciences role?

Candidates must have an MS, PharmD, PhD, RN, or PA degree.

Where is Tango Therapeutics located?

The labs and offices are located at 201 Brookline Avenue in the Fenway area of Boston, Massachusetts.

What is the reporting structure for this position?

You will report to the Senior Medical Director, Clinical Development.

What are the main responsibilities in this role?

Responsibilities include supporting clinical development of oncology therapies, partnering with cross-functional teams for trial execution, contributing to clinical documents, conducting literature reviews, and reviewing clinical data.

Is the salary or compensation mentioned for this position?

This information is not specified in the job description.

Tango Therapeutics

Develops targeted cancer therapies using synthetic lethality

About Tango Therapeutics

Tango Therapeutics develops targeted cancer treatments using the principle of synthetic lethality, which allows them to design drugs that kill cancer cells while leaving healthy cells unharmed. Their approach focuses on the interaction between genes, where the loss of both genes leads to cell death, but the loss of only one does not. This method enables them to create therapies that are more precise in targeting tumors. Tango operates in the oncology market, primarily serving healthcare providers and pharmaceutical companies interested in advanced cancer therapies. They collaborate with larger pharmaceutical firms, like Gilead Sciences, to co-develop their treatments, which helps in funding and speeding up the process of bringing these drugs to market. Tango's goal is to advance their pipeline of targeted immunotherapies through strong research and development efforts and strategic partnerships.

Cambridge, MassachusettsHeadquarters

2017Year Founded

$341.4MTotal Funding

IPOCompany Stage

Biotechnology, HealthcareIndustries

51-200Employees

Benefits

Hybrid Work Options

Risks

Discontinuation of TNG348 due to liver toxicity may affect investor confidence.

Reliance on partnerships for financial support poses risks if partnerships change.

Intensifying competition in precision oncology could impact Tango's market share.

Differentiation

Tango leverages synthetic lethality to target cancer cells while sparing healthy ones.

Their focus includes counteracting tumor suppressor gene loss and immune evasion.

Strategic collaborations with pharma companies accelerate development and commercialization of therapies.

Upsides

Growing interest in synthetic lethality enhances Tango's innovative approach in oncology.

Recent $80 million financing strengthens Tango's financial position for future developments.

FDA clearance for TNG348 and TNG462 boosts Tango's clinical trial advancements.

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