Machine Learning Scientist II/Sr (Omics)

Machine Learning Scientist - Multi-Omics

Salary: $152K - $215K Location Type: Remote Employment Type: Full-Time

Position Overview

Iambic Therapeutics is seeking a talented Machine Learning Scientist to enhance our multimodal transformer, Enchant, by integrating diverse omics signals including genomics, transcriptomics, proteomics, and metabolomics. This role is crucial for advancing our capabilities in target selection and biomarker discovery. You will be responsible for building robust data pipelines, curating benchmarking datasets, and developing sophisticated models that combine multi-omics information with existing context within Enchant. A strong understanding of causal experimental design and the complex interactions between various molecular modalities is essential for success in this position.

Key Responsibilities

• Data Acquisition: Identify, prioritize, and acquire multi-omics datasets.
• Data Pipelines: Build, maintain, and document data pipelines for ingesting, quality-controlling, and harmonizing large multi-omics datasets from both public and proprietary sources.
• Model Development: Design schemes for pretraining and finetuning Enchant on multi-omics data.
• Benchmarking: Define benchmarks for target-selection and biomarker tasks, and source or assemble reference datasets to measure progress.
• Causal Inference: Apply causal inference principles to propose experiments that clarify biological mechanisms and validate model outputs.
• Implementation & Deployment: Write high-quality, tested code and deploy models across multi-GPU or HPC environments, monitoring performance and iterating as needed.
• Research & Mentorship: Stay current with advances in machine learning and computational biology, prototype promising ideas, and share findings with the team. Mentor colleagues in best practices for data engineering, modeling, and experimental design.

Required Qualifications

• Education & Experience: PhD (or equivalent experience) in Machine Learning, Computational Biology, Bioinformatics, Computer Science, or a related field, with a minimum of 3 years of relevant experience.
• Deep Learning Expertise: Demonstrated expertise in applying deep learning techniques to omics data at scale.
• Technical Skills: Proficiency in Python and modern deep-learning frameworks such as PyTorch or JAX.
• Data Pipelines: Experience designing and operating data pipelines for genomics, transcriptomics, proteomics, or metabolomics.
• Causal Inference & Statistics: Solid understanding of causal inference, experimental design, and statistics.
• Software Engineering: Familiarity with software engineering best practices, including version control, code review, and continuous integration.

Preferred Qualifications

• Experience working in cloud or HPC environments and with distributed training.
• Familiarity with multimodal transformers.

About Iambic Therapeutics

Iambic is a clinical-stage life-science and technology company dedicated to developing novel medicines through its AI-driven discovery and development platform. Founded in 2020 and based in San Diego, Iambic has assembled a world-class team that combines pioneering AI experts with seasoned drug hunters. Our platform has a proven track record of accelerating new drug candidates into human clinical trials across various target classes and mechanisms of action. Iambic is actively advancing a pipeline of potential best-in-class and first-in-class clinical assets, both internally and through partnerships, to address critical unmet patient needs.

Learn more about the Iambic team, platform, pipeline, and partnerships at iambic.ai.

Mission & Core Values

Our mission is to deliver better medicines through innovations in AI-based discovery technologies. We believe that the diversity of our people—their backgrounds, cultures, national origins, religions, sexual orientations, and life experiences—profoundly strengthens our culture and work. Iambic Therapeutics is committed to fostering an inclusive environment where a diverse group of talented individuals collaborate to discover therapeutics and create groundbreaking technologies.

Pay and Benefits

We offer industry-leading competitive compensation, company-paid healthcare, flexible spending accounts, voluntary life insurance, 401K matching, and uncapped vacation time. Our team benefits from a brand-new, state-of-the-art facility in beautiful San Diego, featuring an onsite gym, dining options, and convenient access to desirable living and recreational areas.