Associate Scientist/Manager, Translational Medicine at Abata Therapeutics

South San Francisco, California, United States

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Not SpecifiedCompensation

Junior (1 to 2 years), Mid-level (3 to 4 years)Experience Level

Full TimeJob Type

UnknownVisa

Biotechnology, PharmaceuticalsIndustries

Requirements

A 4-yr degree in a relevant science with > 10 years relevant industry experience or MS with 6+ years’ industry experience
Experience with clinical trial biomarker sample logistics and operation required, including sample database and inventory management
Experience with assay development and validation in multiple platforms, e.g., qPCR and ddPCR, LC-MS/MS, ligand binding assays, immunohistochemistry, microscopy, flow cytometry
A background in cardiac biology and disease, genetic diseases, and/or cell or gene therapies preferred
Experience with management of CROs required
Knowledge and understanding of nonclinical and clinical trials and the role of biomarkers and translational medicine within those studies
The ability to manage multiple tasks efficiently, to communicate clearly and effectively

Responsibilities

Manage sample logistics and operations for biomarker sample analysis, collaborating with study management team, central laboratory, specialty lab vendors and data management team
Contribute to nonclinical and clinical trial documents including sample collection sections of study protocols, central laboratory specifications and laboratory manuals, data transfer agreements and study reports
Work with program management and clinical teams to create and manage timelines for biomarker data and report delivery for both nonclinical and clinical study sample analysis
Support contracting for assay development and sample analysis, including development of statements of work and master services agreements with bioanalytical labs
Develop and validate key biomarker assays internally and at CROs for use on nonclinical and clinical trial biomarker samples, including scientific input on assay method development, and document review of plans and reports
Design, execute and interpret experiments to support and broaden the biological understanding of validated biomarker assays, and how the results reflect heart disease progression and response to gene therapy
Data analysis to validate and deepen insights from CRO-generated results of heart disease and immunogenicity biomarkers

Skills

Key technologies and capabilities for this role

biomarker assay developmentsample managementsample logisticsbiomarker sample operationsgene therapyheart failurenonclinical studiesclinical studiesassay developmentdata management

Questions & Answers

Common questions about this position

What is the location or work arrangement for this role?

Tenaya Therapeutics is headquartered in South San Francisco, California, USA. Remote work or hybrid arrangements are not specified.

What salary or compensation is offered for this position?

This information is not specified in the job description.

What key skills and expertise are required for this role?

The role requires expertise in biomarker assay development and sample management across all stages of development, including managing sample logistics, contributing to trial documents, creating timelines, supporting contracting, and developing/validating assays internally and at CROs.

What is the company culture like at Tenaya Therapeutics?

Tenaya Therapeutics values Diversity & Inclusion as a core value, encourages applications from under-represented communities, and emphasizes team tenacity inspired by Tenaya Peak.

What makes a strong candidate for this Associate Scientist/Manager role?

A strong candidate will have experience as a manager or associate scientist in biomarker sample operations management and biomarker assay development, particularly for heart failure gene therapy, with the ability to work across functions.

Abata Therapeutics

Develops therapies for autoimmune diseases

About Abata Therapeutics

Abata Therapeutics develops therapies for autoimmune diseases, focusing on type 1 diabetes. Their main product, ABA 201, is a Treg cell therapy aimed at patients with some remaining beta cell function. This therapy works by utilizing regulatory T cells to improve patient outcomes. Unlike many competitors, Abata targets a specific niche within the autoimmune disease market and collaborates with partners like ElevateBio for process development and manufacturing. The company's goal is to transform treatment options for autoimmune diseases through advanced research and development.

Cambridge, MassachusettsHeadquarters

2021Year Founded

$184.8MTotal Funding

EARLY_VCCompany Stage

BiotechnologyIndustries

11-50Employees

Risks

Intensifying competition from companies like Sangamo Therapeutics may impact Abata's market share.

Stringent FDA scrutiny on manufacturing could delay Abata's clinical trials.

Rising clinical trial costs pose financial risks to Abata's pipeline progression.

Differentiation

Abata focuses on Treg cell therapies for autoimmune diseases like MS and diabetes.

Their lead product, ABA 201, targets type 1 diabetes with remaining beta cell function.

Abata's strategic partnership with ElevateBio enhances their manufacturing capabilities.

Upsides

Recent investment from Bristol Myers Squibb boosts Abata's Treg therapy pipeline development.

FDA's accelerated approval pathways may expedite Abata's clinical trials.

Growing autoimmune disease prevalence increases demand for Abata's innovative treatments.

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