Translational Medical Scientist
NateraSalary not specified
Full Time
Mid-level (3 to 4 years), Senior (5 to 8 years)
Scientist, Single Cell Technology Development & Translational Genomics - (Immunogenomics Group - Biohub NY) at Chan Zuckerberg Biohub
New York, New York, United States
Not SpecifiedCompensation
Senior (5 to 8 years)Experience Level
Full TimeJob Type
UnknownVisa
Biotechnology, Genomics, ImmunologyIndustries
Requirements
- Proven track record in single-cell biology
- Expertise in single-cell genomics workflows
- Experience with molecular biology techniques including assay design, cell manipulation, RNA/DNA isolation, PCR/qPCR, NGS library construction, high-dimensional flow cytometry, and sequencing
- Post-PhD level scientist
- Demonstrated technical expertise and leadership ability (for candidates interested in building and leading a small team of one to two research associates)
- Ability to excel at the intersection of technological innovation, complex biology, and computational analysis
- Highly motivated and collaborative mindset
Responsibilities
- Lead the development of a high-throughput adaptation of scGRO-seq (single-cell nascent RNA sequencing method)
- Design, optimize, and scale high-throughput single-cell/nuclei extraction, barcoding, and library preparation workflows for scGRO-seq
- Integrate scGRO-seq with perturbation-based assays, including CRISPR-based enhancer perturbation, drug treatments, and multi-omics profiling
- Execute advanced molecular biology techniques including assay design, cell manipulation, RNA/DNA isolation, PCR/qPCR, NGS library construction, high-dimensional flow cytometry, and sequencing
- Adapt and validate protocols in patient biopsies and 3D organoid models
- Direct experimental execution, coordinate large-scale data acquisition, and collaborate on downstream analyses with computational biologists
- For qualified candidates: Build and lead a small team (one to two research associates) to implement the assay, conduct perturbation experiments, and oversee data generation
- Generate datasets that drive transformative insights into immune regulation and advance enhancer-guided precision genomic medicine
Skills
Single-Cell Sequencing
Nascent RNA Sequencing
Genome Editing
CRISPR
Functional Screens
Machine Learning
AI
Bulk RNA Sequencing
Immunogenomics
Organoids
Mouse Models
Chan Zuckerberg Biohub
Nonprofit research center for disease understanding
About Chan Zuckerberg Biohub
The Chan Zuckerberg Biohub focuses on biomedical research and technology development. It collaborates with top universities to study the basic mechanisms of diseases and create new diagnostic tools and therapies. The Biohub combines the expertise of engineers, data scientists, and researchers to tackle complex health challenges. Unlike many research institutions, it emphasizes a collaborative approach, pooling resources and knowledge from multiple prestigious universities. The goal of the Chan Zuckerberg Biohub is to advance scientific understanding and improve health outcomes through innovative research.
San Francisco, CaliforniaHeadquarters
2016Year Founded
VENTURE_UNKNOWNCompany Stage
Data & Analytics, BiotechnologyIndustries
51-200Employees