Scientist II/Senior Scientist, In vivo Pharmacology, Oncology at Hexagon Bio

Menlo Park, California, United States

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Not SpecifiedCompensation

Mid-level (3 to 4 years), Senior (5 to 8 years)Experience Level

Full TimeJob Type

UnknownVisa

Biotechnology, Oncology, PharmaceuticalsIndustries

Requirements

PhD in Cancer Biology, Immunology, Pharmacology, or related discipline with 3-5 years of industrial experience
Extensive knowledge of tumor biology
Hands-on experience with in vivo rodent models and ex vivo tissue analysis
Strong knowledge and expertise with multicolor flow cytometry
Experience with tissue immunohistochemistry (preferred)
Experience with coordinating CROs and/or external collaborators (desirable)
Familiarity with ADCs (plus)
Collaborative, team-oriented approach, able to take on problems in a goal-focused fashion
Effective communication and ability to coordinate tasks across multiple projects as part of a multidisciplinary research team
Self-motivation, initiative, and boldness to dive into a fast-paced new startup

Responsibilities

Design and manage in vivo experiments at external vivarium facilities to evaluate the efficacy of antibody-drug conjugates (ADCs)
Drive the selection, development, and characterization of preclinical tumor models, ensuring reproducibility and appropriate use of standard-of-care controls
Develop and execute biomarker assays on tissues using multicolor flow cytometry and immunohistochemistry to support ADC mechanism of action
Design and perform in vitro pharmacology experiments to complement in vivo findings
Analyze and synthesize complex experimental data using appropriate statistical methods, interpret results to guide decision-making processes
Collaborate with a diverse team of biologists, chemists, and CROs to answer scientific questions and deliver quality and timely findings in support of candidate advancement
Effectively communicate findings and interpretation of results to multi-disciplinary teams
Stay abreast of preclinical models applied to ADCs
Comply with company health and safety policies and general laboratory practices

Skills

Key technologies and capabilities for this role

In Vivo PharmacologyAntibody Drug ConjugatesADCsPreclinical Tumor ModelsCRO ManagementOncologyEx Vivo ApproachesDrug DevelopmentPharmacology Experiments

Questions & Answers

Common questions about this position

What is the location for this position?

The position is located in Menlo Park, CA.

What are the key responsibilities of this role?

Key responsibilities include designing and managing in vivo experiments for ADCs at external facilities, developing preclinical tumor models, executing biomarker assays using flow cytometry and immunohistochemistry, performing in vitro experiments, analyzing data, and collaborating with teams.

What qualifications are required for this Scientist II/Senior Scientist role?

A PhD in Cancer Biology, Immunology, Pharmacology, or related discipline with 3-5 years of industrial experience is required, along with extensive knowledge of tumor models.

What is the work environment like at Hexagon Bio?

The role involves working in a highly collaborative, interdisciplinary drug-development team with a mix of laboratory work (80%) and CRO management (20%), emphasizing leadership, scientific curiosity, and effective communication.

What makes a strong candidate for this position?

Strong candidates will have a PhD with industrial experience in relevant fields, demonstrate leadership and scientific curiosity, possess excellent organizational and communication skills, and show passion for collaborative science in drug development.

Hexagon Bio

Biotechnology firm developing medicines using genomics

About Hexagon Bio

Hexagon Bio specializes in discovering and developing new medicines using synthetic biology and data science. They analyze genomic data from various species to identify small molecule inhibitors that target proteins involved in diseases like cancer. Their unique platform allows for rapid production of lead compounds, enabling faster clinical development compared to traditional methods. The company's goal is to create effective treatments for complex diseases and license their drug candidates to larger pharmaceutical companies.

Menlo Park, CaliforniaHeadquarters

2016Year Founded

$178.6MTotal Funding

LATE_VCCompany Stage

Biotechnology, HealthcareIndustries

51-200Employees

Benefits

Flexible Work Hours

Gym Membership

Risks

Faces competition from biotech companies like Insitro and Recursion Pharmaceuticals.

Requires continuous updates to their platform due to rapid technological advancements.

Relies on external funding, posing financial risks if future funding is scarce.

Differentiation

Hexagon Bio uses synthetic biology to discover drugs from fungal genomes.

Their proprietary platform combines data science and synthetic biology for drug discovery.

Hexagon Bio's team includes experts in computational biology, biochemistry, and software engineering.

Upsides

Raised $77.3 million in Series B financing to expand their discovery platform.

Leverages reduced DNA sequencing costs to access vast genomic data.

Partnerships in AI and machine learning enhance drug discovery efficiency.

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