Scientist, Biologics Cell Line Development at Asimov

Boston, Massachusetts, United States

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Not SpecifiedCompensation

Junior (1 to 2 years)Experience Level

Full TimeJob Type

UnknownVisa

Biotechnology, Synthetic BiologyIndustries

Requirements

Ph.D. in Biological Engineering, Cell Biology, Molecular Biology, or a related field with <3 years experience after graduation
Depth of knowledge in areas of biology relevant to how mammalian cells regulate transcription, translation, protein folding & assembly, intracellular trafficking and/or secretion
Interest in genetically engineering cells to support clinical development of human therapeutics
Established as an emerging innovator, interested in applying knowledge and curiosity to work collaboratively and cross-functionally to develop enhanced platforms for production of therapeutic proteins
Creative problem solver excited about driving the creation of industry-disruptive technology
Expert in spreadsheets such as Google Sheets or Excel
Ideally experienced with Spotfire, Google Apps Script (JavaScript) and/or BigQuery to facilitate data management and analysis
Experienced with electronic lab notebooks (Benchling) and meticulous documentation of experiments
Prior experience genetically engineering CHO cells to express mAbs & bsAbs is desirable but not required
Familiarity with cell culture liquid handling automation, ambr bioreactors, and/or ddPCR is a plus

Responsibilities

Perform CHO cell line development processes including transfection, cloning, characterization, and cell banking using state-of-the-art equipment
Drive innovation through the development of novel cell line development workflows and applications
Identify emerging practices for biologics cell line development and manufacturing to shape scientific strategies and develop improved workflows
Represent the cell line development team on cross-functional projects, making decisions for cell line activities
Effectively communicate results, progress, and plans
Conduct CHO-based cell line engineering for biologic therapeutics
Design complex experimental approaches to improve workflows and systems
Coordinate project efforts
Mentor junior scientists
Work closely with Asimov’s synthetic biology and process development teams

Skills

Key technologies and capabilities for this role

CHO Cell Line DevelopmentTransfectionCloningCell CharacterizationCell BankingSynthetic BiologyMammalian Cell EngineeringMolecular BiologyCell Biology

Questions & Answers

Common questions about this position

What is the work arrangement or location for this role?

The role is based in Boston, MA with a hybrid team structure, where the cell line development team works from the new lab and office in Boston’s Fenway neighborhood.

What qualifications are required for this position?

Candidates need a Ph.D. in Biological Engineering, Cell Biology, Molecular Biology, or a related field with less than 3 years of post-graduation experience, along with expertise in mammalian cell biology areas like transcription, translation, protein folding, assembly, trafficking, and secretion.

What salary or compensation is offered for this role?

This information is not specified in the job description.

What is the company culture like at Asimov?

Asimov is a nimble, forward-thinking synthetic biology startup focused on advancing humanity's ability to design living systems, with a collaborative environment where you'll work closely with synthetic biology and process development teams to build the future of biological engineering.

What makes a strong candidate for this Scientist role?

Strong candidates are emerging innovators with a Ph.D. and deep knowledge in mammalian cell biology, a passion for genetically engineering cells for therapeutics, creative problem-solving skills, and proficiency in data tools like spreadsheets, Spotfire, and electronic lab notebooks like Benchling.

Asimov

Synthetic biology solutions for biopharmaceuticals

About Asimov

Asimov operates in the synthetic biology field, providing a combination of cells, genes, and software to assist in advanced genetic design. Their products include cloud-based software that allows clients in the biopharmaceutical industry to design, simulate, and optimize genetic systems. Additionally, they offer engineered GMP host cells that are used for therapeutic applications. Asimov distinguishes itself from competitors by guaranteeing high titer cell lines for monoclonal antibodies with a promise of '4 g/L or it's free,' which reduces risk for their clients. The company's goal is to enable biopharma companies to produce high-quality protein therapeutics and scalable viral vectors efficiently, supported by their in-house expertise in synthetic biology and process development.

Boston, MassachusettsHeadquarters

2017Year Founded

$199.1MTotal Funding

SERIES_BCompany Stage

AI & Machine Learning, BiotechnologyIndustries

51-200Employees

Risks

Competition from LatchBio's code-free biocomputing infrastructure challenges Asimov's software offerings.

Integration of The Foundry may lead to potential cultural clashes and operational disruptions.

Rapid data generation in synthetic biology may strain Asimov's data processing capabilities.

Differentiation

Asimov offers a '4 g/L or it's free' promise for monoclonal antibodies.

The LV Edge Producer System eliminates GMP plasmid costs and reduces process complexity.

Asimov integrates synthetic biology, computer-aided design, and machine learning for genetic design.

Upsides

Stable cell line development reduces costs and increases scalability in lentiviral production.

Acquisition of The Foundry enhances Asimov's expertise in genetic design and engineering.

Growing biotech investments indicate a robust market for Asimov's engineered cell lines.

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