Scientist - Bioassay Screening - Biotherapeutic Drug Discovery at Eli Lilly and Company

San Diego, California, United States

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Not SpecifiedCompensation

Mid-level (3 to 4 years), Senior (5 to 8 years)Experience Level

Full TimeJob Type

UnknownVisa

Biotechnology, PharmaceuticalsIndustries

Requirements

B.S or M.S. in biology, biotechnology, biochemistry, molecular biology, or a related field with 3+ years relevant research experience in assay development & execution, preferably in drug discovery
Proficient in assay development, optimization, miniaturization and troubleshooting of plate-based bioassays in 96/384W formats
Demonstrated ability to significantly reduce optimization timelines through systematic, data-driven approaches
Demonstrated expertise in diverse assay methods and technologies, such as reporter, FRET/BRET, AlphaLISA, HTRF, internalization and co-culture bioassays
Strong proficiency in cell culture techniques, complemented by a foundational understanding of cellular signaling pathways
Demonstrated ability to use multiple software platforms for design-of-experiment, visualization and statistical analysis of large-scale experimental data sets (e.g., Genedata Screener, TIBCO Spotfire, Graphpad Prism, JMP)
Demonstrated ability to successfully take on challenges and quickly adapt to new responsibilities
Experience independently operating automated instrumentation (e.g. dispensers, liquid handlers, acoustic dispensers, multi-mode readers) within a high-throughput setting

Responsibilities

Interface with multiple project teams across the organization and outside Lilly to independently adapt bioassays to mid-high throughput automated formats (96W/384W), validate and execute screens, and identify hits for biologics discovery efforts using state-of-the-art automation platforms
Develop de novo cell-based assays as needed
Leverage AI/ML-driven experimental design and adaptive screening strategies to compress assay development timelines, reduce optimization cycles and generate insights that inform biologics discovery strategies
Apply specialized commercial and internal software tools to perform detailed analysis of biological activity, statistical evaluation of assay performance and generate comprehensive data reports
Engage in the identification and evaluation of novel procedures or technologies that could serve to bolster the productivity of the antibody discovery and protein engineering teams or help in development of new capabilities for the screening group
Proactively identify opportunities to integrate emerging computational tools and automation technologies into existing workflows, including piloting new AI-driven optimization platforms, Bayesian optimization tools, and automated design-of-experiment software that can learn from screening outcomes
Clearly present results to collaborators, participate in project team meetings and present at internal forums
Maintain clear, organized data, SOPs, and electronic notebook entries with great attention to detail

Skills

Bioassay Development

High-Throughput Screening

Lab Automation

Cell-Based Assays

AI/ML

Experimental Design

Statistical Analysis

Data Analysis

384-Well Assays

Biologics Screening

Eli Lilly and Company

Develops and delivers prescription medicines globally

About Eli Lilly and Company

Eli Lilly and Company is a global pharmaceutical company that focuses on discovering, developing, and delivering medicines to improve health. The company has a long history of scientific achievements, including the creation of insulin, the first life-saving treatment for diabetes. Lilly's operations involve extensive research and development to create new medications and enhance existing ones, ensuring they are safe and effective. Their products are primarily prescription medicines sold to healthcare providers for various medical conditions, including diabetes, cancer, and pain management. What sets Lilly apart from its competitors is its strong commitment to ethical practices and the protection of its products from counterfeiting. The company's goal is to enhance lives through innovative medical solutions while maintaining high standards of quality and ethics.

Indianapolis, IndianaHeadquarters

1876Year Founded

$1,180.1MTotal Funding

IPOCompany Stage

Biotechnology, HealthcareIndustries

10,001+Employees

Risks

Competition from Novo Nordisk's Ozempic may impact tirzepatide's market share.

Potential construction delays in Indiana could affect GLP-1 drug production timelines.

Regulatory challenges may hinder Kisunla's expansion in new Alzheimer's markets.

Differentiation

Eli Lilly's rich history includes the first life-saving insulin treatment.

Lilly's strategic partnerships enhance its position in neurodegenerative disease treatments.

FDA approval of Zepbound opens new therapeutic markets for sleep disorder treatments.

Upsides

Lilly's $9 billion complex in Indiana boosts GLP-1 drug production capacity.

Kisunla's approval in China expands Lilly's Alzheimer's treatment market in Asia.

Collaboration with EVA Pharma enhances Lilly's reputation as socially responsible.

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